Current Issue

October  2017

  • Volume 54
  • Issue 10
  • Page Nos. 80

Original Research Articles

Insilico Docking Approach To Study The Binding Affinity Of Isoflavones On The Crystal Structure Of Estrogen Receptor Alpha

PAGE 7-15
The objective of the study was to carry out docking studies of isoflavone derivatives and examine their binding efficiencies to the ligand binding domain of ERα using Autodock program. A series of isoflavone derivatives were computationally designed and optimized with the AutoDock Vina software t...
Sharma T.

Quantitative structure activity relationship modeling for prediction of pyridine substituted analogues with k-Nearest Neighbor studies

PAGE 16-22
A quantitative structure activity relationship study was performed on a series of imidazo[4,5-b]pyridine substituted compounds as angiotensin II receptor antagonists for establishing quantitative relationship between activity and their physicochemical properties. The best quantitative structure ac...
Sharma M. C.* and Kohli D.V.

SYNTHESIS, CHARACTERISATION AND ANTIFUNGAL ACTIVITYOF SOME NEWLY SYNTHESISED POLYSUBSTITUTED PYRAZOLES

PAGE 23-29
A novel series of polysubstituted pyrazoles were synthesised by the cyclization of (α phenoxy/octyl) acetyl aryl hydrazones in presence of formic acid, by refluxing (α-phenoxy/octyl) acetic acid hydrazide and substituted aryl aldehyde, using C2H5OH as solvent. The newly synthesised compounds wer...
Kumar A. and Singh C. P.

Phytochemical investigations of the leaves and flowers of Hibiscus rosa-sinensis L.

PAGE 30-37
Hibiscus rosa-sinensis L. (Malvaceae) is an ornamental and medicinal plant used to treat asthma, cough, boils, wounds, ringworm, gynecological conditions, hair loss, dandruff, itchy scalp, obesity, sexual diseases, cough, cold and venereal diseases. This study was designed to isolate chemical cons...
Ali M.*, Alam P., Singh V., Jameel M. and Sultana S.

SUSTAINED RELEaSE MATRIX TABLETS OF DICLOFENAC SODIUM EMPLOYING KOLLIDON SR, PEG 6000, LACTOSE MONO HYDRATE AND EUDRAGIT S100 IN COLON TARGET

PAGE 38-43
Matrix Tablets, each containing 50 mg of diclofenac sodium, are prepared employing Kollidon SR by direct compression method. All the tablets were found to be non-disintegrating in acidic (pH1.2) and alkaline (pH 7.4) fluids. As such, the prepared tablets were of good quality with respect to drug c...
ch. Taraka Ramarao*, B. Srinivasa Rao and J. Vijayaratana

Stability Indicating Liquid Chromatographic Assessment of Dolutegravir by AQbD Approach – Central Composite Design

PAGE 44-51
Based on the current regulatory requirements for analytical method development, a RP-HPLC method for quality control of dolutegravir in dosage form has been optimized using analytical quality by design (AQbD) approach. Experimental observations were analysed by full factorial experimental design i...
Sunitha G., Anumolu P. D.*, Subrahmanyam C.V.S., Mounika G. and Priyanka B.

Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy(ATR-FTIR) Method for the Determination of Dapagliflozin in Tablets

PAGE 52-57
Dapagliflozin (DAPA) is a promising novel antidiabetic agent, approved by the Food and Drug Administration in 2014. There is a lack of analytical methods for routine quality control of DAPA in pharmaceutical formulations. A validated Attenuated Total Reflectance Fourier Transform Infrared Spectro...
Sabbagh B., Lokesh B. V. S.* and Akowuah G. A.

ANTIARTHRITIC ACTIVITY OF NARDOSTACHYS JATAMANSI ROOT EXTRACT ON FREUND’S ADJUVANT INDUCED ARTHRITIS IN RATS

PAGE 58-64
The present research work was aimed to evaluate anti-arthritic activity of methanolic extract of Nardostachys jatamansi root on Freund’s adjuvant induced arthritis model in rats. Dried root powder was extracted and coded as NJRE (Nardostachys jatamansi root extract). Antiarthritic activity of NJ...
Shah S.*, Shah K. and Patel B.

Short Notes

MONITORING OF CRITICAL PROCESS VARIABLES FOR PILOT PLANT SCALE-UP STUDIES OF PARACETAMOL TABLETS

PAGE 65-67
The objective of the study was to undertake pilot plant scale-up batches of paracetamol immediate release tablets by designing, optimizing and validating the tablet manufacturing process. A process design was developed to define the critical process variables and monitor it throughout the manufact...
Kathpalia H., Sharma K. and Juvekar S.

RP-HPLC Method Development and its Validation for Evaluation of Polyherbal Formulation

PAGE 68-70
Curcumin and embelin, which are the active constituents of Haridra and Vidanga, respectively, were used as marker compounds for developing a simple, accurate, precise and robust RP-HPLC method for simultaneous estimation from Talekt capsule. It is a polyherbal formulation used for enhancing the i...
Sankar K. and Jadhav A. P.*
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