Current Issue

January  2018

  • Volume 55
  • Issue 01
  • Page Nos. 90

Original Research Articles

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1,3,5-TRISUBSTITUTED PYRAZOLINES AS ANTIMALARIAL–ANTIMICROBIAL AGENTS

PAGE 7-14
A convenient and efficient reaction of chalcone for the synthesis of highly functionalized pyrazole and pyridine has been developed. Many pieces of evidence point out the relevance of natural compounds for malaria and its prevention, including chalcones. Ring substituted quinolines are synthesized...
Sonker S.a* and Pathak D.b

DESIGN, SYNTHESIS AND EVALUATION OF NOVEL SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS

PAGE 15-18
A new series of substituted benzimidazole derivatives was synthesis and the structures of these compounds were established on the basis of spectral data. The title compounds were evaluated for in vitro anticancer activity against MCF - 7 and NCI-H226 cell line. Some of these compounds have shown h...
Jadhav S. G*, Pattan S. R, Magdum S. S.c and Patil S. S

Predicting potent antihypertensive compounds of pyridine derivatives by Molecular modeling approach

PAGE 19-25
A quantitative structure activity relationship study was performed on a series of pyridine substituted compounds as angiotensin II receptors for establishing quantitative relationship between biological activity and their physicochemical structural properties. Partial least square (PLS) methodolog...
Sharma M. C* and Kohli D. V

New aliphatic constituents from the aerial parts of Artemisia annua L.

PAGE 26-32
Artemisia annua L. (Asteraceae) is an aromatic annual herb, up to 2 m in height, found in temperate Asia, especially China and naturalized in many countries of the world. The plant is prescribed against fever, malaria, skin diseases, jaundice, malignant ulcers and haemorrhoids. Phytochemical inves...
Singh V.*, Goel R., Rajkumari and Ali M.

IN VITRO ANTI-UROLITHIATIC ACTIVITY OF FRESH JUICE OF CITRUS LIMON (L.)

PAGE 33-36
The study was planned to investigate the anti-urolithiatic activity of fresh juice of Citrus limon L. fruit. The phytochemical screening was also undertaken to reveal the alkaloids, flavonoids, reducing sugar, vitamin C, amino acid and sterols present in the sample. Macromolecule supersaturation o...
Agrawal K. K.*, Singh A. P., Srivastava V. K., Singh S.d and Dubey P.

RAPID SIMULTANEOUS ESTIMATION OF SUMATRIPTAN SUCCINATE AND NAPROXEN SODIUM IN TABLET DOSAGE FORMS USING A VALIDATED STABILITY- INDICATING MONOLITHIC LC METHOD

PAGE 37-43
The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines. The separation was achieved on a Kromosil -ODS C18 (250 X 4.6 mm; 5 μ) column in an isocratic mode. The mob...
S. Ashutosh Kumar*, Debnath M., JVLN Seshagiri Rao, Durga Pavani Anguluri, G. Poorna Sri Ramya, K. Mannaa and Singh M. K

Chemometric optimization for HPLC analysis of simultaneous determination of Tenofovir and Emtricitabine in human plasma

PAGE 44-53
This research paper dealt with chemometric optimization for HPLC analysis of simultaneous determination of the nucleotide tenofovir (TFV) and nucleoside emtricitabine (FTC) reverse transcriptase inhibitors in human plasma. Central composite design and Derringer’s desirability function were used ...
Thomas S.* and Palani Shanmugasundram

HPLC METHOD FOR ESTIMATION OF GALLIC ACID AND EMBELIN IN AVIPATHI CHOORNAM- AN AYURVEDIC FORMULATION

PAGE 54-60
In the present study, an attempt has been made to develop an analytical method for the simultaneous estimation of gallic acid and embelin in marketed Ayurvedic polyherbal formulation Avipathi choornam by High Performance Liquid Chromatography (HPLC). The chromatographic separation was performed o...
Jadhav A. P.* and Mali S. D.

Evaluation of Antioxidant, Hypoglycaemic, Antidiabetic and Alpha amylase Inhibiting Activities of Sargassum Wightii Collected From the East Coast of India

PAGE 61-69
This study evaluated the antioxidant, hypoglycemic, antidiabetic and alpha amylase inhibiting activities of Sargassum wightii. Antioxidant activity of ethyl acetate and methanol extracts of this seaweed was evaluated and extract having promising antioxidant activity was further studied for hypogly...
Mohapatra L.*, Bhattamisra S. K., Panigrahy R. C. and Parida S.

Study of key stakeholders for their knowledge, attitude and practice on Adverse Drug Reaction reporting in tertiary care hospitals in Jaipur, India

PAGE 70-80
Adverse drug reactions (ADR) are the leading cause for the hospital administration, morbidity, and mortality as per the established data. Present pharmacovigilance program of India is performing well for strengthening ADR reporting system. The current project is aimed to study knowledge, attitude ...
Sharma R.*

Short Notes

Formulation and Evaluation of Buoyant Microspheres of Nizatidine by Spray drying Technique

PAGE 81-83
The objective of the present investigation was to formulate multiparticulate buoyant dosage form of nizatidine, a H2-receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. The short biological half-life (1 -2 hours), maximum absorption in initial part of small intestine, colonic...
Palekar N. G.*, Keny R. V., and Jagtap V. A.
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