Current Issue

April  2018

  • Volume 55
  • Issue 04
  • Page Nos. 92

Guest Editorial

Self-sufficiency in manufacture of APIs and Intermediates is a necessity for the Indian Pharmaceutical Industry

PAGE 5
Active Pharmaceutical Ingredients (APIs) are key raw materials to produce pharmaceutical finished dosage forms like tablets, capsules, syrups, ointments etc. Swift growth in new innovations is prodding the interest for generic active pharmaceutical ingredients manufacturers worldwide with the exp...

Review Article

THE EVOLVING CONCEPT OF CAVEOLINS AND INTERMEDIARY ROLE IN VARIOUS MECHANISMS VIA BIOMOLECULAR PATHWAYS

PAGE 7-17

Caveolins are integral membrane proteins which consist of caveolae, present in plasma membrane. Many researchers have reported the role of caveolae in major physiological conduits of the mammalian cells, including cholesterol homeostasis, transcytosis and endocytosis. Caveolin also play a role in...

Upadhyay P. K. a* and Vishwakarma V. K. b

Original Research Articles

NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

PAGE 18-26

Novel Schiff’s bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was...

D. Sai Priya a, Kini S. G a*, Bhatt V. G a, Rathi E. a, Muralidharan A. b and Koteshwara A. b

Simultaneous Determination and Quantitation of Metformin and Teneligliptin in human plasma by LC-ESI-MS/MS with an application to pharmacokinetic studies

PAGE 28-38

‘Gliptins’ is the nickname given to a group of anti-diabetic medicines-DPP-4 inhibitors, such as sitagliptin, vildagliptin, sexagliptin, linagliptin, alogliptin and teneligliptin, which are used with metformin for combination therapy of type 2 diabetes mellitus. Advantages of this combined th...

Mandal P. a, Dan S. b, Ghosh B. c, Barma S. a, Bose R. d and Pal T. K. b*

Method development and validation of lenvatinib by HPLC and UV-Spectroscopy

PAGE 39-47

A simple rapid, accurate, precise and reproducible validated UV spectroscopy, RP-HPLC method was were developed for the determination of lenvatinib in bulk forms. The quantification was carried out using HiQSil 4.6 X 250 mm, 5μ, C8 column, run in isocratic way using mobile phase comprising of me...

Patve R. S. M a*, Shaikh A. R. b, Inamdar N. c, Bhise K. d

Stability Indicating Assay Method of Sirolimus Using HPLC and Separation of Acid Degradant by HPTLC

PAGE 48-55

A stability indicating RP-HPLC method has been developed and subsequently validated for Sirolimus. The proposed RP-HPLC method utilizes Phenomenex, C18, 3 μm, 4 mm x 150 mm column, mobile phase consisting of acetonitrile and water (65:35 V/V) and UV detection at 277 nm using a photodiode array d...

Jadhav S. a*, Pisal P. a and Mahajan M. a

Development of sirolimus coated eluting stent using abluminal coating technology

PAGE 56-62

The current study focuses on the development of abluminal coated stent using blend of sirolimus and poly L-lactide-co-caprolactone as the biodegradable polymer. The abluminal coating of stents presume to reduce the systemic side effects and provide targeted tissue release. To compare outcome of a...

Shah N. V. a*, Jariwala A. B. b, Raval A. J. b, Seth A. K. a and Aundhia C. J. a

Isolation of Tecomine from Alkaloid Fraction, Investigation of Adaptogenic and Neuropsychopharmacological Effectsof Ethanolic, Ethyl Acetate and Hexane Flower Extracts of Tecoma gaudichaudi

PAGE 63-74

The present study aims to evaluate antistress and neuropharmacological parameters of ethanolic, ethyl acetate and hexane flower extracts of Tecoma gaudichaudi. Forced swim stress was used to evaluate antistress activity. The 24 h urinary excretion of vanillylmandelic acid (VMA) and ascorbic acid ...

K. Ravishankar a, G.V.N. Kiranmayi a*, and Y. Rajendra Prasad b

Short Notes

NEW ECO-FRIENDLY TITRIMETRIC ANALYSIS OF FRUSEMIDE TABLETS USING MIXED HYDROTROPIC SOLUBILISATION

PAGE 75-76

In the present study, a blend of 15% w/V sodium salicylate, 5% w/V niacinamide, 5% w/V sodium acetate and 5% w/V sodium citrate was prepared to carry out titrimetric estimation of frusemide tablets. The solubility of frusemide in distilled water at room temperature was found to be 0.64 mg/mL. The...

Maheshwari R. K. and Gupta J. *

DEVELOPMENT AND VALIDATION OF RP-HPLC-PDA METHOD FOR THE ESTIMATION OF SARPOGRELATE HYDROCHLORIDE IN BULK AND DOSAGE FORMS

PAGE 77-80

A simple and precise RP-HPLC method has been developed and validated for the estimation of sarpogrelate hydrochloride, an anti-platelet drug in bulk and pharmaceutical dosage forms. Sarpogrelate is an antagonist at 5HT2A and 5HT2B receptors which blocks serotonin induced platelet aggregation and ...

Vijaya Lakshmi M. *, Hima Bindu K., Pravallika M. and Nalluri B. N.

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