Articles Accepted

APPLICATION OF CHEMOMETRIC METHODS FOR DETERMINATION OF CLOTRIMAZOLE AND BECLOMETHASONE DIPROPIONATE IN PHARMACEUTICAL DOSAGE FORM
by Dr. Umang H Shah, 06 Oct 2018

Chemometric is the use of mathematical and statistical methods to improve the understanding of chemical information and to correlate quality parameters or physical properties to analytical instrument data. In current work, two chemometric methods named as principal component regression (PCR) and PLS partial least square (PLS) based on the use of spectrophotometric data were developed for simultaneous determination of Clotrimazole (CLO) and Beclomethasone dipropionate(BEC) in bulk and cream form. The absorbance of zero order UV spectrums of CLO and BEC in the range of 80-400 μg/ml and 2-10 μg/ml, respectively were recorded in the wavelength range 230-272 nm at 3 nm wavelength interval. Twenty-five (25) mixed solutions were prepared for the chemometric calibration as training set and sixteen varied solutions were prepared as a validation set. The suitability of the models was decided based on the RMSECV, RMSEP and PRESS value of calibration and validation data. The % recovery study of both the method was compared, and it was found nearer to each other. The assay of CLO and BEC for both the method was found in range of 99.78 to 101.20%. Hence, the proposed methods can be used for simultaneous analysis of the mixture of the t drugs, without chemical pre-treatment, the speed of analysis.

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