In conventional methods of medication, Marsdenia tenacissima (family: Apocynaceae) is used, in the treatment of scurvy, urinary diseases, arthritis, heart disease, skin disease, pruritus, vomiting and intermittent fever. Estimation of biological activities confirmed that Marsdenia tenacissima plant shows antipyretic, antioxidant, anticancer and anti-HIV activity. This assessment presents the phytochemical constituents, traditional importance and pharmacological activities accounted for the plant and it will be supportive to explore incisive information about Marsdenia tenacissima for the researchers.