Articles Accepted

POTENTIATING MICONAZOLE ACTIVITY WITH CLOVE OIL AND CHITOSAN IN MICROEMULSION BASED GEL FOR TRETMENT OF FUNGAL INFECTION
by Ms. Durga Pandey, 03 Dec 2018

The aim of the study was to investigate the in vitro antifungal activity of miconazole entrapped in microemulsion based gel with clove oil as permeation enhancers and chitosan as an antifungal agent. SEM confirms spherical droplets of microemulsion in the 2 micron size range. Viscosity of emugel was 2251 cP, excellent spreadability 31.27 ± 0.219 gm.cm/cc as compared to marketed formulation. pH was 5.528 ± 0.032, excellent homogeneity, Drug content 98 % in optimized batch. Not any drug excipients interaction reported in FTIR spectroscopy. In-vitro drug release showed 94.8% in 6 hrs. Ex-vivo skin permeation showed higher steady state flux than conventional cream. Antifungal activity on Candida albicans showed zone of inhibition more than marketed preparation. No major changes in viscosity, spreadability, homogeneity and drug content observed during stability study. Thus it can be concluded that the formulation may hold some promise for treatment of severe fungal infections.

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