Articles Accepted

TELMISARTAN TABLET FORMULATION AND DEVELOPMENT BY FACTORIAL DESIGNS AND STABILITY ACCESSMENT
by Dr. Ch. Taraka Ramarao, 16 Feb 2019

Telmisartan tablets were studied in 23 factorial designs employing selected combinations of 3 factors (β Cyclodextrin, Binders, disintegrants) of eight formulations of telmisartan tablets were prepared and evaluated. All the telmisartan tablets were prepared good quality with regard to drug content, hardness, friability and disintegration time to fulfill official (IP) specifications of uncoated tablets. Many variations were observed in all the dissolution parameters of tablets prepared due to formulation variables. The ANOVA of dissolution rate (K1) indicates the individual main effect and combined effect of β Cyclodextrin, Binders, disintegrants on the dissolution rate constant (K1) are significant (P Fc > Fac > Fab > Fb > Fa > F1. The optimize telmisartan tablets (Fabc) formulated employing1:2 ratio of β Cyclodextrin, Gelatin (2%) and Primogel(5%) are compare to the marketed product (mytel 80). The differential factor (f1) valued found 5.776 and similarity factor (f2) value found 75.291. Differential factor (f1) and similarity factor (f2) indicate identical/similar dissolution profile comparable to marketed product (mytel80).The stability studies were conducted as per ICH guidelines.

Current Issue
November 2020
Quick Contact