Articles Accepted

AMELIORATIONS IN INSULIN RESISTANCE AND Β-CELL FUNCTION BY DPP-4 INHIBITION POTENTIAL OF TRIGONELLA FOENUM SEED EXTRACT IN TYPE-2 DIABETIC RATS
by Dr. Heera Ram, 16 Mar 2019

pancreas protection by DPP-4 inhibition potential of Trigonella foenum (TF) seed extract in corticosteroid induced type-2 diabetic rats by slilico, in-vitro and in-vivo assays. The corticosteroid induced diabetic status of animal model was considered at the HOMA indices, insulin and glucose levels. While, the in-vitro assay of DPP-4 inhibition shown up to 60.4±2.8% and activity of DPP-4 in serum was observed 39.12±1.3% in T. foenum seed extract treated groups. Furthermore, the FTIR spectra interpreted availability of potent functional groups in possessing bioactive compounds. Additionally, HPLC studies confirmed that gallic acid is the leading compound possess in T. foenum seed extract shown significant binding energy obtained from -3.6 -3.7 with DPP-4 residues LYS-71, ASN-74, GLU-91, THR-94, PHE-95, ILE-102, ASN-103, and ASP-104 via hydrophobic bonds. The significant changes were observed in HOMA indices, histopathology and others supportive parameters in treated groups. treated groups. Therefore, the study revealed promising results against insulin resistance, β-cell function and protective alterations in pancreas.

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August 2019
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