Articles Accepted

In-Vitro Characterization of Antifungal Activity of Selected Essential Oils
by Dr. chandi charan rath, 14 Apr 2020

In the present investigation, we studied the antifungal activity of seven essential oils primarily against C. albicans and E. floccosum through Disc Diffusion Method (DDM). Four essential oils viz. Turmeric, Palmarosa, Lemongrass and Citronella that revealed better antifungal activities against the test pathogens during screening were characterized further. Minimum Inhibitory Concentration (MIC) values of the oils ranged between 0.97 to 62.5 µl/ml. When the oils were treated at high temperature (1000C for 1hr) and pressure (autoclaved), also showed antifungal activities, indicating thermostable and barostable nature of the active components present in it. The oils showed resistance to sonication (33,000Hz for 30min) too as the sonicated oils retained the antifungal activities against the two pathogens. The oils killed E. floccosum immediately, resulting in an irreversible damage to the cells. The phenol coefficient value of the oils ranged between 0.125-.75. The antifungal activity of these oils as recorded during the study, could be attributable to the membrane inhibition mechanism and observed to be fungicidal in nature.

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November 2020
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