Articles Accepted

In this present study, a novel series of Chalcones (C1-10) were synthesized by reacting 4- Nitro acetophenone and various substituted aromatic aldehydes in alcohol medium. The title compounds Pyrimidine derivatives (PD1-10) were yielded by the cyclization of chalcones (C1-10) with Guanidine carbonate in alcoholic medium. All the newly synthesized compounds were structurally assigned with FT-IR, 1H-NMR and Mass spectral data. The synthesized compounds were subjected for In-Silico analysis among which, some of the synthesized compounds were chosen and evaluated for In-Vivo Anticonvulsant study by employing, PTZ induced seizure and MES seizure models. Compounds, PD2 and PD7 demonstrated significant anticonvulsant activity, when compared to the standard.