Articles Accepted

CELLULOSE ACETATE FLOATING MICROSPHERES OF METFORMIN HYDROCHLORIDE: FORMULATION AND CHARACTERIZATION
by Dr. AJAY SEMALTY, 25 Sep 2020

In this study, floating microspheres of Metformin hydrochloride were prepared by using cellulose acetate polymer. The method employed was solvent evaporation. Various formulations were prepared by varying the ratio of drug and polymer. The prepared microspheres were then subjected to various evaluation parameters such as drug content, micrometric evaluations, FTIR, SEM, floatability and in- vitro dissolution study. Formulation F1 (1:1 ratio of polymer and drug) showed the highest drug release and drug content with the good flow properties. The cumulative percentage of drug release significantly decreased with decreasing drug concentration with a constant polymer ratio. Scanning Electron Microscopy images of all formulations showed that the prepared floating microspheres were irregular in shape, and the surface was found to be non- uniform and rough. In-vitro release studies indicated the mechanism of the drug release to follow the Korsmeyer-Peppas model, and “n” value was found to be between 0.5-1.9, indicating anomalous transport mechanism.

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November 2020
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