Articles Accepted

Antidiabetic Activity on Methanolic Extract of Cucumis Dipsaceus Ehrenb. (Fruit) in Streptozotocin- Induced Diabetic Rats.
by Dr. SUMAN LATA, 23 Jul 2019

The present study was designed to investigate the hypoglycemic and antidiabetic properties of Cucumis dipsaceus fruit which are widely used in the Indian traditional medicine for the treatment of diabetes. In present study, to investigate the antidiabetic action of the methanolic extract of Cucumis dipsaceus fruits in Streptozotocin induced-diabetic rats. The antidiabetic activity of methanolic extract of fruit Cucumis dipsaceus was evaluated by using normal and Streptozotocin induced-diabetic rats. The acute effect of methanolic extract was evaluated by administering 500 mg/kg p.o. to normoglycemic rats. In the chronic model, the methanolic extract was administered to normal and STZ-induced-diabetic rats at dose of 500 mg/kg p.o. per day for 21 days. Blood glucose levels and body weights were observed at specific intervals and different biochemical parameters were also carried out. Methanolic extract (500 mg/kg) produced a significant reduction in blood glucose level in STZ- induced diabetic rats. The statistical data indicated the significant increase in the body weight and serum insulin level and decrease in the glycosylated hemoglobin levels. Total cholesterol level was decreased while an increase in HDL and LDL cholesterol level was observed when treated with the extract. The methanolic fruit extract of Cucumis dipsaceus exhibited significant anti-hyperglycemic activities and beneficial effects in reducing the elevated total cholesterol level of STZ-induced-diabetic rats.

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October 2019
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