Articles Accepted

Hydrophobic Ion-Paired Drug Delivery System; A narrative review
by Dr. Maha, 09 Aug 2019

Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase, this could affect a higher permeation through biological membranes. HIP complexation was considered through the formation of a neutral molecule by electrostatic interaction of ionizable groups of drugs with oppositely charged functional groups of a complex-forming agent, subsequently, this ion-pair may encapsulate into many delivery systems. The objective of this manuscript was to study the effectiveness of ion-pair and cover the update application of this strategy through several routes of administration as ocular, oral, pulmonary, transdermal, and parenteral.

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October 2019
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