Articles Accepted

PULSATILE DRUG DELIVERY SYSTEM: APPROACHES AND CURRENT PROSPECTIVE REVIEW
by Mr. Garje Mahesh Arjun, 12 Sep 2019

Pulsatile drug delivery system is chronopharmacotherapeutic system which releases the bioactive agent at correct time and at desired site according to biological need. The body shows circadian rhythm in physiological processes. This is novel approach which shows rapid and transient release of active drug in sufficient concentration after specified lag time upon administration. Drug is released according to circadian rhythm of body. Many times constant drug release is not necessary for treatment. As constant release therapy are not sufficient to treatment and side effects can be observed many time. Hence, pulsed drug release after lag time is more effective to treat the diseases. Pulsatile delivery system are used to treat various physiological disorders such as asthma, hypertension, diabetes, arthritis, peptic ulcers and cardiovascular diseases etc. Different pulsatile formulations developed such as hollow calcium pectinate beads for floating pulsatile drug delivery, pulsatile tablets, capsular systems, hydrogels, implantable devices, etc. using different smart polymers. Drug is released by various mechanisms like rupturing or erosion, floating system, solubility modulation. Drug release is triggered as response to various internal physiological factors such as pH, enzymes, hormones, temperature etc. or external stimuli like ultrasound, magnetic and electrical stimulation. Pulsatile drug delivery system classified into different classes like capsular system, multiparticulate system, internal stimuli responsive system and external stimuli responsive system. Recently developed technologies such as Pulsincap, IPDAS, Geoclock, CODAS are novel technologies in pulsatile drug delivery system in market.

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