Articles Accepted

UV-SPECTROPHOTOMETRIC DETERMINATION OF PARTITION COEFFICIENT (LOG P) OF OLEANOLIC ACID AND ITS COMPARISON WITH SOFTWARE PREDICTED VALUES
by Mr. NILESH BANARASE , 30 Nov 2019

Oleanolic acid is reported to have various pharmacological activities of therapeutic interest. In order to use it in the modern therapy, it is necessary to understand about its drug designing parameters. The current study deals with the determination of partition coefficient (log p) of oleanolic acid by UV-spectrophotometer and its comparison with the values predicted by the softwares. For the determination of partition coefficient of oleanolic acid, the shake-flask method was used in which the drug is allowed to partition between n-octanol and distilled water. Further, the amount of drug solubilized in the n-octanol was determined using the UV-spectrophotometer. The partition coefficient of oleanolic acid obtained by said method is 5.32. While, the various online software predicted its log p value ranging from 3.94 -7.9. The log p value of oleanolic acid obtained by experiment and predicted by the various softwares concluded that the said molecule is lipophilic in nature.

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