Articles Accepted

IMPROVEMENT OF WATER SOLUBILITY AND IN VITRO DISSOLUTION RATE OF DEFLAZACORT BY COMPLEXATION WITH β-CYCLODEXTRIN THROUGH FREEZE DRYING PROCESS
by Dr. Nilesh S Kulkarni, 11 Dec 2019

Deflazacort is a poorly water soluble drug practically insoluble in water. The objective of the study is to improve the solubility of Deflazacort by using solubility enhancer as β-cyclodextrin and also to study the effect of water soluble polymer as PEG 4000 on solubility of Deflazacort:β-cyclodextrin binary system. The inclusion complexes of Deflazacort with β-cyclodextrin in 1:1 w/w, 1:2 w/w and 1:3 w/w proportion was prepared by kneading, microwave irradiation and freeze drying technique. The inclusion complexes were evaluated for in-vitro dissolution studies and characterized by Fourier transform infrared spectroscopy, Differential scanning calorimerty, Powder x ray diffraction study, 1H Nuclear Magnetic resonance spectroscopy and scanning electron microscopy study. The in-vitro dissolution study showed improved dissolution rate for Deflazacort for freeze dried binary Deflazacort:β-cyclodextrin 1:2 w/w as compared to ternary Deflazacort:β-cyclodextrin: PEG 6000 1:2 w/w complexes, plain Deflazacort, physical mixture and complexes prepared by kneaded and microwave technique. This is confirmed by Fourier transform infrared spectroscopy, Differential scanning calorimerty, Powder x ray diffraction study, Scanning electron microscopy and 1H Nuclear Magnetic resonance spectroscopy study. Thus, Deflazacort: β-cyclodextrin with improved solubility was successfully developed using freeze drying as novel technique.

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