Articles Accepted

A SYSTEMATIC REVIEW ON MUCOADHESIVE BUCCAL DELIVERY OF DRUGS, ITS CHALLENGES AND PRESENT ASPECTS
by Mrs. Sayani Bhattacharyya, 21 Jan 2020

Buccal delivery is an interesting route of delivery owing to its easy administration of drugs. Buccal delivery releases the drug into oral cavity and promotes absorption through the oral mucosa and trans-mucosa to achieve local and systemic actions of drug. This route of delivery can be successfully used to attain site-specific release of drug on mucosa. The suitable architecture of oral mucosa makes it suitable for delivery of drugs that extensively undergo hepatic first pass and presystemic metabolism. The limited surface area for absorption, mucosal barrier and other physiological activities limits the rate of absorption from oral cavity. The obstacles of oral route can be overcome using mucoadhesive dosage forms with innovative drug delivery systems. This review addresses the anatomical features of oral cavity, barriers in drug absorption from oral cavity, possible ways of oral drug delivery, mucoadhesion and the recent developments in mucoadhesive buccal delivery.

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May 2020
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