Articles Accepted

Evaluation of Toxicity and Antiasthmatic Potential of an Ayurvedic Formulation on experimental Animal
by Mr. Raj Kumar Tiwari, 03 Feb 2020

Objective: To explore acute, chronic toxicity and antiasthmatic potential of ayurvedic formulation on experimental animals. Background: Asthma is chronic inflammatory hyper-responsiveness disease of the airways characterized by wheezing, coughing and breathlessness. There are many ayurvedic formulations which are being used traditionally for the treatment of various diseases. Nayopayam Kashayam is an ayurvedic formulation used by traditional practitioners for the treatment of respiratory disease like hiccup, bronchial asthma, gas trouble, cardiac diseases. Despite its several uses, the safety profile of the formulation is not still being reported. The present study was targeted for the study of its toxicity profile along with its Antiasthmatic activity. Methods: The toxicity study was carried out using OECD 425 CPCSEA guideline in albino wistar rats. Oral acute toxicity study was performed at 2000mg/kg orally, which was considered as limit dose. The chronic toxicity study was carried out with administration of Nayopayam Kashayam at three therapeutic equivalent doses i.e. TED (45mg/kg, orally), TEDx5 (225 mg/kg, orally) and TEDx10 (450 mg/kg, orally) for 90 days. Further antiasthmatic study was carried out using Histamine induced bronchospasm in guinea pig model. Result: The result of acute toxicity showed that drug did not create any signs and symptoms of toxicity or no mortality was shown to an oral dose of 2000 mg/ kg in rats. The results of chronic toxicity study showed that the drug even at level as high as dose of TEDx10 had no significant effect at all on hematological and body weight parameters. The drug but, at dose of TEDx10 showed mild to moderate unfavorable changes in kidney and liver. The experiential changes were not seen at the lower dose levels. The drug also showed a marked decrease in hiccups of asthma during antiasthmatic study. Hence, it is suggested that the Nayopayam Kashayam, prepared as per the traditional method, is secure for utilization and treatment of asthma at the therapeutic dose level.

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