Articles Accepted

Design and Evaluation of Chitosan-HPMC Polymeric Films for the Transdermal Delivery of Captopril
by Dr. Rajesh Sreedharan Nair, 05 Feb 2020

Drug permeation through the skin layers remains a major challenge in the transdermal drug delivery. In this study, the permeation enhancing property of chitosan combined with its rate-controlling property is been utilized in the development of an efficient transdermal delivery system using a model drug captopril. Chitosan- Hydroxypropyl methylcellulose (HPMC) films were developed by solvent evaporation technique. The films were characterized for appearance, thickness, weight uniformity, drug content, folding endurance and moisture absorption. Drug-polymer interaction was assessed using ATR-FTIR spectroscopy and Differential Scanning Calorimetry. The in-vitro permeation was carried out in Franz-type diffusion cells using synthetic Strat-M® membrane demonstrated that the film coded F2 (Chitosan: HPMC = 50:50) had shown significant increase in drug permeation than F1 (Chitosan: HPMC = 90:10) with a flux value 86.7 µg/cm2/hr. The physicochemical characterization and the stability studies confirmed that the formulated films were chemically and physically stable.

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