Table of Contents

June  2014

  • Volume 51
  • Issue 06
  • Page Nos. 1-49

Review Article

New and emerging HDAC inhibitors for the treatment of diseases

PAGE 5-15
Histone deacetylases (HDACs) are critical in regulating gene expression and transcription. They also play a fundamental role in regulating cellular activities such as cell proliferation, survival and differentiation. Inhibition of histone deacetylases has generated many fascinating results includi...
Mahajan S.S*, Chavan A.

Original Research Articles

Self-emulsifying Drug Delivery System Containing Aceclofenac: Design & Development using Quality by Design (QbD) Concept

PAGE 16-26
The aim of the present study was to develop self-emulsifying drug delivery system (SEDDS) of aceclofenac for potential improvement in the in vitro dissolution. The Food and Drug Control Agency (FDCA) has put more stress on the quality, safety and efficacy of the dosage form. The use of design of ...
Suthar V., Gokel M., Butani S., Solanki A.

DESIGN DEVELOPMENT AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF RANITIDINE HYDROCHLORIDE

PAGE 27-36
The aim of this study was to develop an innovative fast dissolving oral film of Ranitidine HCl based on polymers such as Hydroxy Propyl Methyl Cellulose-E6, Hypromellose-E3 LV, and Polyvinyl alcohol. Trials on various concentrations of polymers were conducted in order to optimize polymer concentra...
Ramana B.V*., Triveni C., Nagarajan G., Murthy T.E.G.K.1

Gastroretentive Floating Microsphere of Nateglinide: Formulation, Evaluation and Effect of Drug-Polymer Ratio

PAGE 37-43
The study aims to develop gastroretentive floating drug delivery system of nateglinide which is used in the treatment of type – II diabetes. Due to the short biological half life of drug (about 1.5 hours), frequent dosing is required to maintain its therapeutic effect. Therefore, to prolong the ...
Semalty A*, Semwal A

Bioprospecting for Cyclodextrin Glycosyltransferase producing bacteria

PAGE 44-48
Cyclodextrin glycosyltransferase- (CGTase), (EC.2.4.1.19) producing micro-organisms were isolated from different sources of soil (paddy plantation, potato plantation, garden and Malpe beach) from places in and around Udupi, India. A potential isolate MBS 24 was identified as Virgibacillus pantothe...
RajeshY., Narayanan K., Subrahmanyam V.M.* and Venkata Rao J.

Short Notes

DESIGN AND EVALUATION OF DOMPERIDONE FAST DISINTEGRATING TABLETS BY WET GRANULATION TECHNIQUES USING PLANTAGO OVATA MUCILAGE

PAGE 49-54
In the present study, fast disintegrating tablets of domperidone were prepared to enhance patient compliance by wet granulation method. In the study, fast disintegrating tablets of the drug using, Plantago ovata mucilage and Crospovidone were used as superdisintegrants (2.5 to 10 % w/w) along wit...
Shahidulla S M*, Mohib khan, Jayaveera K N
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