Table of Contents

December  2018

  • Volume 55
  • Issue 12
  • Page Nos. 108

Guest Editorial

Open Innovation in Indian Pharma

PAGE 5-6

Times are changing for the pharmaceutical industry. Once secretive about their research and priorities, companies are becoming more open in sharing their aspirations and bringing new ideas from outside to fuel their innovation.

...

Dr. Ganesh Deshpande
Editorial Advisory Board
Indian Drugs

Original Research Articles

In silico Docking Studies, Synthesis and Chacterization of Some Novel 1,3,4 Thiadiazole Analogues of 4-amino Hippuric Acid as Potent Antimicrobial agents

PAGE 7-17

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. The heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and b...

Daniel K.a* and Daniel V.b

SYNTHESIS, ANTI-ARTHRITIC AND ANTIOXIDANT ACTIVITIES OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

PAGE 18-23

A series of novel 2,5-disubstituted-1,3,4-oxadiazoles (2a-j) were synthesized by the reaction of 4-hydroxy benzhydrazide (1) and aromatic aldehydes (2) in the presence of small amounts of ferric chloride in methanol as solvent medium. The synthes...

Banylla Felicity Dkhar Gatphoha, B. C. Revanasiddappaa*, M.Vijay Kumara and Hemanth Kumara

IN VITRO DNA BINDING STUDIES OF SELECTED HETEROCYCLIC COMPOUNDS

PAGE 24-26

DNA binding studies of selected heterocyclic compounds belonging to the class of quinolinones, substituted quinolinones and thiones were carried out using ct-DNA. The binding nature of the compounds with DNA analyzed using UV-spectroscopy revealed the compounds to be DNA intercalators demonstrati...

Akhila C.a and Lalitha P.a*

Effect of Ethanolic Extract Fractions of Rosa centifolia in Doxorubicin-induced Myocardial Toxicity in Albino Rats

PAGE 27-33

This study was undertaken to understand the preventive role of ethanolic extract fractions of flower petals of Rosa centifolia (RC) against Doxorubicin-induced myocardial toxicity in albino rats. The ethanolic extract of flower petals of RC was prepared by hot extraction method and furth...

Nimbal S. K.a and Koti B. C.a*

FORMULATION AND EVALUATION OF FAST DISSOLVING FILM OF FOSINOPRIL

PAGE 34-40

The mouth dissolving film overcomes the shortfalls of conventional quick dispersing/dissolving intraoral tablets. Fosinopril is an angiotensin converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of chronic heart failure.It undergoes extensive hepatic first pass...

Pande V.V.a , Patel A.A.b , Patel V.P.a* and Khedkar P.V.a

Stability-indicating reversed-phase HPLC method for the separation and estimation of related impurities of Cilnidipine in pharmaceutical formulations

PAGE 41-49

A novel HPLC method was developed and validated for the determination of cilnidipine (CLDP) along with its related impurities A and B in pharmaceutical formulations. The chromatographic separation was carried out by isocratic elution using an X Terra C18 column (250×4.6mm; 5μ). The mobile phase...

Bikshal Babu Kasimalaa, Venkateswara Rao Annaa and Useni Reddy Mallua*

HILIC TECHNIQUE BASED HPCL ANALYSIS OF CAPTOPRIL, GLUTAMIC ACID AND TAURINE FROM VARIOUS MATRICES

PAGE 50-59

A simple and rapid chromatographic method using HILIC technique has been developed for simultaneous estimation of captopril, glutamic acid and taurine from their admixture as well as from biological matrices. Determination was carried out on Luna HILIC column (4.6 mm x 250 mm, 5 μm) using a mobi...

Jadhav S. D.a* and Bhatia M. S.a

PANCREATIC LIPASE INHIBITORY AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF FLORETS OF ASTER SPECIES

PAGE 60-68

Pancreatic lipase inhibitory effect of methanolic extract of florets Aster sp. was studied. In case of Aster sp. (White florets) the pancreatic lipase inhibition recorded was 82.75% with an IC50 value of 38μg/mL. Aster sp. (light pink) showed 80.04 % inhibition with an IC50...

Shahu R. R.b, Rathod P.a,b, Kulkarni C.a,b, Mhatre S.a,b and Yadav R. P.a,b*

Comparative antioxidant activity of hydro-alcoholic Polyherbal formulations (HAF-I & HAF-II) in immobilised stress induced rat model

PAGE 69-77

The present study was undertaken to develop a method and to assess the anti-stress activity of poly herbal formulation HAF-I & HAF-II in immobilised stress induced rat model. Acute toxicity study was performed according to OECD guidelines No. 423. Sprague Dawley female rats were observed peri...

Srivastava A. K.a*, Kaushik D.b and Lal V. K.c

Short Notes

Enhacement of solubility profile of plumbagin containing tablet at different colonic region for colon targeting drug delivery system

PAGE 78-82

The aim of present study is to improve solubility profile of a poorly soluble anti-cancer natural product, plumbagin at colonic site through incorporation of β-cyclodextrin by preparing complexes by a number of methods. Natural compound plumbagin have lower solubility profile in various GIT medi...

Jain N.a* and Kori M. L.a

Development And Evaluation of modified release matrix tablets of milnacipran HCL using melt granulation technique

PAGE 83-85

The objective of the present study was to identify critical formulation parameters affecting the drug release from modified release wax matrix tablet of milnacipran hydrochloride employing the concept of design of experiments. The optimized amount of Compritol 888 ATO (intragranular) (X1), lactos...

Ratnakar N. C.a* and Gohel M. C.b

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