Table of Contents

February  2019

  • Volume 56
  • Issue 02
  • Page Nos. 92

Guest Editorial

Anti-Microbial Resistance: An Opportunity to Collaborate

PAGE 5-6

Dr George Patani, is a Pharmacist from the College of Pharmaceutical Sciences, Manipal and completed his Masters in Medicinal Chemistry and Ph.D. in Drug Delivery from the Rutgers, The State University of New Jersey. He has approx. 18 years’ experience at the INGA group of companies, developing...

Dr. George Patani,
Associate Editor,
Indian Drugs

Original Research Articles

Design, synthesis and molecular mechanism of few neuraminidase inhibitors in treatment of H1N1 by NMR techniques

PAGE 7-15

Considering the issue of resistance to anti-influenza drugs, there is a need for discovery of new antiviral drugs. In view of this, flavones and their synthetic precursors i.e. chalcones were designed as inhibitors of influenza virus - H1N1 neuraminidase enzyme using structure-based drug design. ...

Jadhav P.a, Borkar M.a, Malbari K.a, Joshi M.b and Kanyalkar M.a*

A NOVEL APPROACH TOWARDS GREEN SYNTHESIS OF ZINC NANO PARTICLES FROM GUAZUMA ULMIFOLIA (LAM) FOR THEIR ANTI OXIDANT ACTIVITY STUDY

PAGE 16-20

Here we report a novel biological approach for the formation of zinc nanoparticles using Guazuma ulmifolia (Lam) leaves. Zinc acetate was reduced with aqueous solution of Guazuma ulmifolia leave extracts. X-Ray diffraction (XRD) pattern reveals the formation of zinc nanoparticles, which shows cry...

Nannapaneni U. R.a* and Rayapati S. R.b

FORMULATION AND DEVELOPMENT OF EXTENDED RELEASE MATRIX PELLETS OF WATER INSOLUBLE AZILSARTAN MEDOXOMIL WITH SOLID DISPERSION

PAGE 21-30

The present study involved the design and development of extended release matrix pellets of azilsartan medoxomil with its solid dispersion (Azil SD). A solid dispersion of azilsartan medoxomil was prepared with a carrier, Hypromallose acetate succinate (Affinisol 716G) by solvent evaporation tech...

Pande V. V.a, Sanklecha V. M.a* and Arote S. R.b

HPLC Method Development, Validation, and Forced Degradation for Simultaneous analysis of Oxycodone and Naltrexonein Pharmaceutical Dosage Form

PAGE 31-38

A simple, precise and stability-indicating RP-HPLC method was developed for simultaneous quantification of oxycodone (OXCD) and naltrexone (NTRX) in combined dosage form. The developed method was validated with respect to precision, linearity, accuracy, robustness, ruggedness, sensitivity and sol...

Phani R. S. Cha, Prasad K. R. S. a and Useni R. M.b*

A New Stress Indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Ertugliflozin and Metformin in bulk and its Tablet Dosage Form

PAGE 39-46

A simple, accurate, precise and robust reversed phase high performance liquid chromatographic (RP-HPLC) method was developed for the estimation of Ertugliflozin (ETZ) and metformin (MFN) in bulk and in tablet dosage form. The method was carried out by used Waters (5μm, C18 250 x 4.6 mm) column w...

D. China Babua*, C. Madhusudhana Chettyb and Sk. Mastanammac

Development and Validation of stability indicating RP-HPLC method for estimation of Pitavastatin Calcium in bulk and tablet dosage form

PAGE 47-56

An isocratic stability-indicating reverse phase high performance liquid chromatographic diode array detection method has been developed and validated for the quantitative determination of pitavastatin calcium in the presence of its degradation products. The chromatographic separation was achieved...

Suhagia B. N.a, Akabari A. H. a*, Shah S. A.b and Shah D. R.b

Anti-inflammatory and antinociceptive activities of gymnemic acid in Wistar rats

PAGE 57-63

The present study was aimed to evaluate anti-inflammatory and antinociceptive activities of gymnemic acid (GA) in Wistar rats. The different doses of GA were tested for their anti-inflammatory in carrageenaninduced rat paw oedema animal model by using buzzer assisted plethysmograph and antinocice...

Karale S. a*, Kulkarni V. H. a and Aswathanarayana B. J.a

EVALUATION OF IN VIVO ANTIOXIDANT ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF LINUM USITATISSIMUM L. (TUKHM-E-KATAN) AGAINST HIGH FAT DIET INDUCED RATS

PAGE 64-72

The aim of the present study was to evaluate the in vivo antioxidant activity of 50% ethanolic extract of Linum usitatissimum against high fat diet induced rats. Animals were treated with plant extract for 30 days, and high fat diet was given to all groups except plain control through, out the st...

Khan Z. J.a*, Khan N. A. a, Naseem I.b and Nami S. A. A.c

Short Notes

STUDY OF BUCKWHEAT (FAGOPYRUM ESCULENTUM) SEED POWDER AS A TABLET BINDER

PAGE 73-76

The aim the study was to expand the area of tablet binders from gums and extracted polysaccharides to whole seed powders so as to reduce processing cost involved with other synthetic binders and involvement of whole seed benefits to single dosage form. In the present study, buckwheat seed powder ...

Singh P.a*, Kashikar V.b, Shinde V.a and Tayade J.a

RAPID RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF LURASIDONE HYDROCHLORIDE IN BULK AND TABLET FORM

PAGE 77-83

RP-HPLC method was developed and validated for the estimation of lurasidone hydrochloride as per ICH guidelines. A simple, fast, accurate and precise RP-HPLC method was developed by using acetonitrile: water containing 0.01% ortho phosphoric acid in the ratio of (50:50)v/v. The method was develop...

K. Vijaya Sri a*, M.Shiva Kumar a and A. Sravani a

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