Table of Contents

April  2019

  • Volume 56
  • Issue 04
  • Page Nos. 100

Guest Editorial

Collaboration and Commitment hold the key for New Drug Development in India

PAGE 5-6

Dr Madhu Dikshit is a leading scientist of the country and has made significant contributions to the general area of Molecular Pharmacology with special interest in redox biology. Dr Dikshit has impacted the area of neutrophil biology, by enhancing our understanding on how nitric oxide modulates ...

Dr. Jay Lakshman
Director/Global Technical Project Management

Original Research Articles

A GREENER APPROACH TO SYNTHESIS OF DIACEREIN

PAGE 7-12

Diacerein, also known as diacetylrhein (1,8-diacetoxy-3-carboxyanthraquinone), is a slow-acting active pharmaceutical ingredient of the anthraquinone class used to treat joint diseases such as osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1 beta and demonstr...

Gangurde S. A.a*, Laddha K. S.a and Joshi S. V.*b

SYNTHESIS AND ANTICANCER ACTIVITY OF NOVEL 2-BENZYL-6- (SUBSTITUTED PHENYL)-IMIDAZO[2,1-B] [1,3,4] THIADIAZOLE DERIVATIVES

PAGE 13-20

A new series of 2-benzyl-6-(substituted phenyl)-imidazo[2,1-b][1,3,4] thiadiazoles (S1-S8) was synthesized as potential anti-cancer agents. These compounds were evaluated for their anticancer activity against various cancer cell lines. The anticancer activity data reveals that the compounds S1 (2...

Singh S.a* and Kaur Amandeepb

COMPARATIVE EVALUATION OF IN VITRO ANTIMICROBIAL AND IN VIVO WOUND HEALING ACTIVITY OF ETHANOLIC AND ETHYL ACETATE EXTRACTs OF ABUTILON INDICUM ROOT

PAGE 21-31

The present study was aimed at comparing the in vivo wound healing and in vitro antibacterial activity of Abutilon indicum roots. Wound healing is a complex phenomenon which consists of three stages inflammatory, proliferative, and remodelling. Traditionally, A. indicum is used ...

Ravishankar K.a, Kiranmayi G.V.N.a* and Sruthi J. M.a

FINGER PRINTING ANALYSIS OF THE PHENOLS FROM PERGULARIA DAEMIA FORSK PLANT LEAVES and stem USING HPTLC

PAGE 32-36

The research study was carried out to identify the phenols from methanol extracts (MPD) of medicinally and efficiently useful leaves and stem of Pergularia daemia (Forsk) plant using High Performance Thin Layer Chromatography (HPTLC) technique. Preliminary phytochemical screening was don...

Sutar N G.a*

OFLOXACIN ION PAIRING WITHIN SUBMICRON EMULSION: A POTENTIAL APPROACH FOR OCULAR DELIVERY

PAGE 37-44

The aim of the work was to improve the entrapment of ofloxacin within the submicron emulsion by ion pairing with sodium deoxycholate to improve antimicrobial activity and precorneal retention. Partition coefficient of ofloxacin-sodium deoxycholate was found to be 3.788, compared to 0.113 for the ...

Pandey D.a*, Singh R.a, Jain S.b and Jain D.a*

SYNERGISTIC EFFECT OF NIGELLA OIL AND CLOTRIMAZOLE AS ETHOSOMAL GEL FOR IMPROVED TREATMENT OF FUNGAL INFECTIONS

PAGE 45-49

The aim of this research work was to develop an ethosomal gel containing nigella oil encapsulated with clotrimazole (CLT) for improved antifungal activity. The ethosomes were prepared using soya lecithin (SpC) and Nigella oil (NO) as lipids by thin film hydration and they exhibited a particle siz...

Momin M.a*, Butte K.b and D’Souza A.c

COMPARATIVE EVALUATION OF IN VITRO ANTIOXIDANT AND IN VIVO HEPATOPROTECTIVE ACTIVITIES OF ETHANOLIC LEAF AND ROOT EXTRACTS OF CLEOME GYNANDRA

PAGE 50-56

In vitro antioxidant and in vivo hepatoprotective activities of Cleome gynandra ethanolic leaf and root extracts were assessed. In vitro antioxidant activity was carried by DPPH, Nitric oxide, hydroxyl radical and phosphomolybdenum assays. Hepatoprotective acti...

Ravishankar K.a, Lakshmi Prasanna Y.V.V.M.a, and Kiranmayi G.V.N.a*

Short Notes

ANALYSIS OF LEAD AND CADMIUM IN SELECTE D INDIAN AYURVEDIC MEDICINES BY ICP-AES

PAGE 57-60

Herbal drugs used in treatment of diabetes, require long-term usage and the patient might be at risk of heavy metal poisoning. This study has been conducted to determine the concentration of heavy metals Pb and Cd in ten (10) commonly used anti-diabetic medicines of different brands. 6 out of 10 ...

Pande A.a*

LYCOPENE AND BETANINS BASED HERBAL LIPSTICK

PAGE 61-64

Colouring the skin particularly skin of face or lips, is an ancient practice going back to prehistoric times. The use of such coloring products has increased and the choice of shades of colour, texture and luster have changed and become wider. The present study was aimed at formulation and evalua...

Agarwal S.*a, Vandanaa, Bajaj H.a, Yadav M.a and R. Singha

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