Table of Contents

May  2019

  • Volume 56
  • Issue 05
  • Page Nos. 84

Guest Editorial

Current Concerns – USTR Report and Biodiversity Guidelines

PAGE 5-6

Dr. Gopakumar G. Nair is a Ph.D in Organic Chemistry (1966) from National Chemical Laboratory, Pune (Pune University). He was a Post-Doctoral fellow at IIT Bombay, Powai (1967) before joining the Pharma Industry. He was Director of Bombay Drug House P. Ltd., later Chairman of BDH Industries Ltd. ...

Dr. Gopakumar G. Nair

Editor, Indian Drugs

Original Research Articles

Extraction, quantitative determination and spectral identification of Carnosic Acid – a diterpene antioxidant from Rosmarinus officinalis

PAGE 7-13

Carnosic acid is a benzenediol abietane diterpene having antioxidant and other medicinal activities. The medicinally active compound carnosic acid was isolated from leaves of the herb Rosmarinus officinalis. A simple solid-liquid extraction with solvent acetone in Soxhlet extractor was u...

Usha Rani N.a* , Prasad Rao P.T.S.R.K.b

DESIGNING A PLATFORM TECHNOLOGY FOR AGE APPROPRIATE PEDIATRIC DOSAGE FORM

PAGE 14-23

Present work was aimed to develop a platform technology for pediatric dosage form which masks the bitter taste of a drug and to prepare flexible solid oral dosage form using hot melt extrusion (HME). Eudragit EPO, a cationic co-polymer insoluble in pH above 5, was used as a taste masking polyme...

More D. M.*a, Chaudhari P. D.b and More S. D.c

A Validated Spectrofluorimetric Method for Determination of Polysorbate 80 from Pharmaceutical Formulation

PAGE 24-29

A simple, rapid and sensitive spectrofluorimetric method has been developed and validated for the determination of the non-ionic surfactant, polysorbate 80, from pharmaceutical formulation. The proposed method is based on a fluorescence enhancement of the probe (eosin B dye) with addition of p...

Parmar V. K.a* and Brahmbhatt H. R.b

RP-HPLC AND HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DOLUTEGRAVIR IN BULK AND TABLET DOSAGE FORM

PAGE 30-38

Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), antiretroviral drug. RP-HPLC and HPTLC methods have been developed and validated for DTG in bulk and tablet dosage form. In HPLC method, analysis was carried out on C-18 column using a mixture of acetonitrile...

Ghante M. R.*a, Sawant S. D.a Undre M.a, Jagtap S. G.a, Kulkarni P.and Nikam V. S.a

INVESTIGATIONS ON IN VITRO METABOLITES OF LINEZOLID In Various species

PAGE 39-49

Linezolid is a potent synthetic oxazolidinone used for the treatment of bacterial infections with a new mechanism of action that involves early inhibition of bacterial protein synthesis. In humans, linezolid circulates mainly as parent drug and is excreted primarily as parent drug and a major i...

Kesana S. L.*a, Vamaraju H. B.b, Dodle J. P.a and Sastry P. C.c

SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-PHENYLPYRIDO[2,3-D] PYRIMIDINE DERIVATIVES AS CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS

PAGE 50-58

We report a novel scaffold of 2-phenylpyrido[2,3-d]pyrimidine derivatives designed as structural analogues of dinaciclib. Sixteen derivatives were synthesised and evaluated for their CDK2/5 inhibition activity. Compounds 4-(2-(3-methoxybenzylidene)hydrazineyl)-2-phenylpyrido[2,3-d]pyrimidine (7i)...

Bhagwanrao P. V.a*, Ingole P. G.a, and Butle S. R.a

Short Notes

Synthesis and Antimicrobial Evaluation of 3,4-Dihydropyrimidin- 2(1H)-one Analogs

PAGE 59-63

This paper reports synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via a three component condensation reaction. The synthesized molecules were tested against bacterial strains Bacillus subtilis and Escherechia coli and against fungal strains Candida alb...

Darekar M.a and Mehendale M. S.a*

Preparation, Evaluation and Optimization of Mucoadhesive Mini Tablets of Telmisartan by Using Single Unit Encapsulation System

PAGE 64-67

The objective of the present study was to develop and optimize capsule filled oral mucoadhesive minitablets of telmisartan. Wet granulation method was employed for the development of minitablets. All the formulations (F1- F13) exhibited more than 21% drug release at 4h and at the end of 12h it sh...

Patil I. S.a* Patil O. A.a, Chavan R. R.a,

Randive D. S.a, Bhutkar M. A.a and Bhinge S. D.a

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LINAGLIPTIN AND EMPAGLIFLOZIN

PAGE 68-71

A simple, accurate and precise RP-HPLC method was developed for the simultaneous estimation of the linagliptin and empagliflozin in tablet dosage form. Chromatogram was run through Kromasil 250 x 4.6 mM, 5mM column, mobile phase containing 0.1% o-phosphoric acid buffer and acetonitrile in the ...

Lakshmana Rao A.a*, Prasanthi Ta. and Anusha E. La.

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