Table of Contents

June  2019

  • Volume 56
  • Issue 06
  • Page Nos. 96

Review Article

CURRENT UPDATES ON DIAGNOSTIC BIOMARKERS OF HEPATOCELLULAR CARCINOMA

PAGE 7-23

Hepatocellular carcinoma (HCC) is a liver malignancy, which is a cause of several deaths related to cancer worldwide. In early stages, curative treatment such as surgical resection, liver transplant and local ablation can improve the patient’s survival. However, the disease is often diagnosed i...

Hasan N.a, b*, Mukim M.b, c, Sharma P.c, Baghel U. S.c and Khalid M.b,

Original Research Articles

SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED-2-THIENYL- 5-(4-CHLOROPHENYL) PYRAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS

PAGE 24-30

Cancer is not a single disease, but a large group of diseases characterized by uncontrolled, rapid and pathological proliferation of abnormally transformed cells. Pyrazoline is a five-membered heterocyclic ring having two adjacent nitrogen atoms within the ring. It has only one endocyclic double ...

Kaur Amandeep a , Kaur Baljeet a and Gupta Monika a*

Pharmacognostic standardization of Jacaranda mimosifolia leaves and stem bark

PAGE 31-36

pharmacognostic standardization is a basic criterion to assure authenticity and quality of any medicinal plant. In the present study micromorphological examinations along with proximate analysis, fluorescence and elemental analysis of Jacaranda mimosifolia leaves and stem bark were carried out. M...

Patrakar R. G. a* and Bhusnure O. G. b

PREPARATION AND IN VITRO EVALUATION OF BIODEGRADABLE ZIDOVUDINE LOADED CONTROLLED RELEASE MICROSPHERES USING NATURAL GUMS AS RELEASE RETARDANTS

PAGE 37-45

The objective of the present investigation was to evaluate the entrapment efficiency of the anti-HIV drug, zidovudine, using natural gums and study the zidovudine release. Zidovudine-loaded microspheres were prepared by external ionotropic gelation technique. Sodium alginate in combination with g...

Sai S. M. a , Swain R. P. a* and Mahapatra A. K. b

VALIDATION OF NEW LIQUID CHROMATOGRAPHIC METHOD FOR NATURALLY ISOLATED QUERCETIN AND ITS COMMERCIAL APPLICATION TO AYURVEDIC FORMULATION

PAGE 46-50

Quercetin was isolated from Aerva lanata (L) and investigated for method development. A simple, accu- rate, reproducible method was developed using RP-HPLC. Commercial formulation of Quercetin 250mg capsules (Quercetin Complex-Solgar, USA) was used followed by an Ayurvedic proprietary medicine fo...

Dinnimath B. M. a* and Jalalpure S. S. b

THYMOL AND EUGENOL LOADED CHITOSAN DENTAL FILM FOR TREATMENT OF PERIODONTITIS

PAGE 51-58

The main objective of this study was to formulate an intrapocket chitosan (CS) dental film loaded with thymol (TH) and eugenol (EU) for the treatment of periodontal diseases. The antibacterial and antifungal efficacy of TH (5mg/mL) measured in terms of zone of inhibition against S. mutans was 10...

Patole V. C. a*, Chaudhari S. P. a , Pandit A. P. b and Lokhande P. P. b

DEVELOPMENT AND VALIDATION OF RP HPLC METHOD FOR THE ESTIMATION OF SOFOSBUVIR IN BULK, TABLET AND INDUSTRIAL WASTE WATER

PAGE 59-66

The study was aimed at development and validation of RP-HPLC method for estimation of sofosbuvir in bulk, pharmaceutical dosage form and pharmaceutical industrial waste. The chromatographic separation was performed on Agilent Syncronis C 18 (100 mm × 4.6 mm, 5μm) column, with a mobile phase com...

Dhanunjayachary V. a , Likhitha V.L.S. b , Vijaya Sri K. a* and Madhuri M. A. a

DEVELOPMENT AND VALIDATION OF A CHEMOMETRICS ASSISTED SPECTROSCOPIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF GALLIC ACID, ELLAGIC ACID AND CURCUMIN IN POLYHERBAL ANTIDIABETIC FORMULATIONS

PAGE 67-73

Two chemometric methods, Inverse Least Square (ILS) and Classical Least Square (CLS), were applied for the simultaneous estimation of gallic acid, ellagic acid and curcumin in polyherbal antidiabetic formulation. Twenty mixed solutions were prepared for the chemometric calibration as training set...

Shah M. A. a,b* , Patel H. U. c and Raj H.A. d

EFFECT OF ESCULETIN ON OSSIFICATION OF NOTOCHORD OF ZEBRAFISH LARVAE AND AMPUTATED CAUDAL FIN OF ZEBRAFISH ADULTS

PAGE 74-76

Esculetin, a natural coumarin, has anti-osteoclastic activity on cell line. We studied the effect of esculetin in vivo. Zebra fish larvae were raised in water containing various concentrations of esculetin. The area and intensity of ossified notochord was measured. Toxicity study of esculetin on ...

Pherwani P. U. a,b and Sathaye S. a*

SELECTION OF BEST CRYSTAL STRUCTURE FOR INITIATING DOCKING-BASED VIRTUAL SCREENING STUDIES OF CDK2 INHIBITORS: A CROSS-DOCKING AND DUD SET VALIDATION APPROACH

PAGE 77-85

A total of 95 crystal structures of CDK2 were selected after considering criteria such as resolution and absence of missing residues in the active site; and subjected to cross-docking. 14 out of 95 crystal structures exhibited docking accuracy for greater than 70% of ligands at RMSD cut off 2Å i...

Joshi A. a , Bhojwani H. a , and Joshi U. a*

Short Notes

IN VITRO ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT AND DIFFERENT FRACTIONS OF CENTELLA ASIATICA LEAVES BY PROTEIN DENATURATION

PAGE 86-89

Inflammation might be a complex organic reaction to a hazardous stimulant such as pathogens, or injured tissues and mainly causes itching, swelling, skin redness, warm and slight pain. Herbal drugs are widespread in India for their effectiveness, easy availability at low cost and provide low toxi...

Sharma S. a* , Trivedi R. b and Choudhary N. K. c

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