Table of Contents

July  2019

  • Volume 56
  • Issue 07
  • Page Nos. 100

Guest Editorial

Our National Health and Research Policy: Progressive Changes

PAGE 5-6

Dr. Nagaraj Narayan Rao obtained Bachelor’s degrees in Science (Chemistry) and in the Technology of Pharmaceuticals and Fine Chemicals from the University of Mumbai. After working with Colgate-Palmolive (India) for two years as a laboratory chemist, he obtained his doctorate in science with mag...

Dr. Nagaraj N. Rao

Associate Editor

Review Article

CURRENT UPDATES ON DIAGNOSTIC BIOMARKERS OF HEPATOCELLULAR CARCINOMA

PAGE 7-15

Hepatocellular carcinoma (HCC) is a liver malignancy, which is a cause of several deaths related to cancer worldwide. In early stages, curative treatment such as surgical resection, liver transplant and local ablation can improve the patient’s survival. However, the disease is often diagnosed i...

Kumbham S.a, Ghate V.a and Lewis S. A.a*

Hasan N.a, b*, Mukim M.b, c, Sharma P.c, Baghel U. S.c and Khalid M.b,

Original Research Articles

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF SOME NEWER BENZIMIDAZOLE DERIVATIVES BY MANNICH REACTION

PAGE 16-22

o-phenylenediamine and salicylic acid were used for the synthesis of 2-(1-(substituted phenylamino) methyl-1H benzo[d] imidazol-2-yl) phenol (2a-2h) derivatives by using various substituted aniline. In the first step, reaction of o-phenylenediamine and salicylic acid yielded 2-(1H-benzo[d]imidazo...

Kumar N. a* and Pathak D.b

Development and Validation of Rapid and Simple Bioanalytical Method for Docetaxel with One Step Protein Precipitation

PAGE 23-32

A rapid and simple bio-analytical method with one step protein precipitation and extraction using acetonitrile as extraction solvent was developed for docetaxel. The extraction efficiency was 87.81% with satisfactory separation of docetaxel and IS peaks by isocratic elution with C18 column (25 cm...

Mehendale P. C.a, Athawale R. Bb, and Singh K. K.a

DEVELOPMENT AND CHARACTERIZATION OF SUBLINGUAL FILM CONTAINING ROPINIROLE HYDROCHLORIDE

PAGE 33-42

In the present work films of ropinirole hydrochloride were prepared by using polymers such as hydroxy propyl methyl cellulose (HPMC E-15) and polyethylene glycol (PEG-400) as plasticizers, by a solvent casting method, for treatment of Parkinson's disease. HPMC E-15 was used as film forming agent ...

P. B. Patila, D. A. Patila, L. R. Zawarb, B. Patilb and G. B. Patil*b

DEVELOPMENT AND VALIDATION OF A NEW RP HPLC METHOD FOR ROUTINE DETERMINATION OF TEA TREE OIL IN BULK AND COSMECEUTICAL FORMULATIONS

PAGE 43-49

Tea tree oil, an active ingredient of skin, hair and nail care cosmeceuticals, has claims for topical antimicrobial, analgesic and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. Terpinene-4-ol is the principal constituent of the oil (35% - 48%) followed by γ-te...

Manjula B.p.*a, Joshi V. G.a, Ramachandra Setty Siddamsettya, Geetha Ma

STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF PIOGLITAZONE, AMLODIPINE, ATORVASTATIN AND CLOPIDOGREL

PAGE 50-58

A new simple, rapid, isocratic and stability indicating reverse phase high performance liquid chromatography (HPLC) method has been developed for simultaneous estimation of pioglitazone (P), amlodipine (AM), atorvastatin (AT) and clopidogrel (CP). Isocratic separation was achieved on Millennium M...

Monikaa, Pandey S.b and Chawla P.a,c*

Simultaneous Estimation of Curcumin and Gefitinib in Bulk and Tissue samples (Plasma and Brain homogenate) by RP-HPLC: Application to a Distribution Study

PAGE 59-68

The present study was aimed at developing a Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) method for simultaneous determination of curcumin (CRM) and gefitinib (GFT) in bulk, plasma and brain homogenate. hydrochlorothiazide was used as an internal standard (IS). A new simple, ra...

Mahajan H.a*, Savale S.a and Nerkar P.a

in vitro antioxidant and in vivo hepatoprotective activity of ethanolic extract of Ziziphus rugosa Lam. leaves

PAGE 69-75

Ziziphus rugosa Lam. belongs to the family Rhamnaceae and is found chiefly in deciduous and semi evergreen forest of Western Ghats. The present research was undertaken to establish in vitro antioxidant and in vivo hepatoprotective activity of ethanolic extract of Z.rugosa Lam. leaves. The powdere...

Parashar S.a, Uplanchiwar V.b, Gautam R. K.c* and Goyal S.d

IN VITRO ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF DESMODIUM TRIFLORUM

PAGE 76-79

The ethanolic extract of Desmodium triflorum (EEDT) was investigated for in vitro antiurolithiatic activity by using nucleation and aggregation methods. phytochemical screening was also undertaken to reveal the presence of alkaloids, flavonoids, reducing sugars and sterols in the sample. The In v...

Revanasiddappa B.C.a*, Vijay Kumar M.a, Shanmukha I.b, Kumar H.a and Aishwarya T. C.a

Short Notes

summary of chromatographic analysis methods of anti diabetic gliflozins Empagliflozin, Canagliflozin and Dapagliflozin

PAGE 80-83

Sodium glucose co-transporter-2 (SGLT-2) inhibitors are relatively new developed effective oral anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. They present either alone or in combination with other ant diabetic agents such as linagliptin, Saxagliptin and metformin. Therefore,...

Zaghary W. A.a, Mowaka S.b,c,d, and Hendy M. S.b,d

1,3,7,8-SUBSTITUTED XANTHINE DERIVATIVES AS POTENTIAL ANTIASTHMATIC AGENTS WHICH ACT ON ADENOSINE RECEPTOR

PAGE 84-87

Asthma is one of the most common chronic diseases in modern society. There is a high prevalence of usage of complementary medicine for asthma. Xanthine derivatives which act on adenosine receptor have been cited as a most popular complementary treatment. This studys was undertaken to determine if...

Shringi M.a* and Baregama C.a

Formulation and Evaluation of Fast Dissolving Tablets of Loratadine Solid Dispersion Using Super disintegrants

PAGE 88-91

Loratadine is a water-insoluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of Loratadine using super disintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. The SD’s...

Kumar S.a, Kumar J. V.a and Singhal P.b*

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