Table of Contents

August  2019

  • Volume 56
  • Issue 08
  • Page Nos. 94

Guest Editorial

Disruptive innovation at the interfaces of the drug industry

PAGE 5-6

Dr V. Premnath is currently the Head, NCL Innovations – the group within National Chemical Laboratory (NCL) charged with the responsibility of championing the cause of technology innovation within NCL. Dr Premnath is also the Director of the Venture Center – a technology business incubator on...

V. Premnath, Ph.D.
Head, NCL Innovations & Director, Venture Center
CSIR-National Chemical Laboratory, Pune

Review Article

Topical delivery of drugs using ethosomes: A review

PAGE 7-20

The skin is the largest organ of the human body that restricts the movement of drug to the systemic circulation. Topical drug delivery system is a system where the drug reaches the systemic circulation through the protective layer i.e. skin. The main disadvantage of this route is the low diffusio...

Sankar V.a*, Wilson V.a, Siram K.a, Karuppaiah A.a, Hariharan S.b and Justin A. c

Original Research Articles

DESIGN, SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF QUINOLIN-2-ONE DERIVATIVES

PAGE 21-26

Starting material 4-hydroxy-1-phenyl/methyl-quinolin-2-(1H)-one was treated with phosphorous oxychloride and then subjected to Mannich reaction to yield title 4-chloro-1-phenyl/methyl-3-[3- (substituted) propanoyl] quinolin-2(1H)-one derivatives compounds IIa (1-7)/ IIb (1-7). Molecular docking s...

Emmie de Abreua, Chandavarkar S. K.b*, Biradar B. S.c, Bobde S. S.d, Naik S. P.a and Mamledesai S. N.a

PHYSICOCHEMICAL PROPERTIES DETERMINATION OF PICROSIDE-II

PAGE 27-37

The aim of the present study is to determine the physicochemical properties of Picroside-II, a phytochemical obtained from the herb of Picrorhiza kurroa. The solubility study of picroside-II shows that it has better solubility in water up to 2.46 mg/mL than organic solvents. The solubility of pic...

Bhusari S.a*, Chaudhary A.a, Shrangare G.a, Rindhe M.a and Wakte P.a

LIPID NANOPARTICLES FOR TRANSDERMAL DELIVERY OF CELECOXIB: AN IN VITRO AND IN VIVO INVESTIGATION

PAGE 38-48

In the present research work, celecoxib (CXB) loaded solid lipid nanoparticles (SLNs) were prepared using the probe sonication method, wherein Glyceryl monostearate and Tween 80 were used as solid lipid and surfactant, respectively. To obtain the statistically optimized batch, 32 factorial design...

Shinde S. V.a*, Nikam S.a, Raut P.a and Ghag M. K.a

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TENELIGLIPTINE HYDROBROMIDE HYDRATE (TEN) AND METFORMIN HYDROCHLORIDE (MET) IN TABLET DOSAGE FORM

PAGE 49-56

A simple, accurate, precise, reproducible and economic method developed and validated for the simultaneous estimation of teneligliptine hydrobromide hydrate (TENE) and metformin hydrochloride (MET HCl) in pharmaceutical dosage form. TENE and MET HCl were estimated on Thermoscientific C18 column u...

Joshi H.a, and Khristi A.a*

DEVELOPMENT AND VALIDATION OF UV-SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF SELEGILINE HYDROCHLORIDE LOADED SOLID LIPID NANOPARTICLES

PAGE 57-60

The present paper discusses about a simple, precise and validated method for the determination of selegiline loaded solid lipid nanoparticles. The study was carried as per the parameters laid down in ICH guidelines. Maximum wavelength of selegiline in 8:2 methanol: chloroform mixture was selected...

Prajapati J. B.a*, Rao H.b and Shah H.C

High Performance Liquid Chromatographic - Diode Array Detector Method for Simultaneous Estimation of Escitalopram oxalate and Flupentixol dihydrochloride in Combination

PAGE 61-68

The proposed work involves High Performance Liquid Chromatographic – Diode Array Detector method for estimation of escitalopram oxalate and flupentixol dihydrochloride in combination. The analytes were resolved on Waters C18 Xterra column (50 × 4.6 mm id, particle size 3.5 μm) with mobile pha...

Gawande V. V.a* And Chandewar A. V.a

EXPLORATION OF PROTECTIVE EFFECT OF HYDROALCOHOLIC EXTRACT OF ALSTONIA SCHOLARIS BARK IN STZ-INDUCED EARLY DIABETIC NEPHROPATHY MODEL IN RATS

PAGE 69-78

Alstonia scholaris (fam. Apocynaceae) is an indigenous plant used traditionally for the treatment of diabetes and associated complications. However the nephroprotective potential of the plant is not scientifically evaluated. Objective of the present was to investigate renal protective activity of...

Bandawane D. D.a*, Jadhav S. B.a and Juvekar A. R.b

Short Notes

QUANTITATIVE ASSESSMENT OF VASICINE AND VASICINONE IN DIFFERENT MARKETED FORMULATIONS USING HPLC

PAGE 79-80

The main aim was to study the variation in vasicine and vasicinone concentration in different marketed cough syrups using HPLC with photo-diode array detector. Since the marketed formulations were containing Adhathoda vasica extract of varying amount, the amount of vasicine, which is the main con...

Akhade M. S.a* and Laddha K. S.

SIMULTANEOUS DETERMINATION OF DOMPERIDONE AND PARABEN PRESERVATIVE IN ORAL FORMULATION: REVERSED-PHASE LIQUID CHROMATOGRAPHIC METHOD

PAGE 81-83

A novel RP-HPLC method was developed and validated for the determination of compounds in an oral solution. The method describes the determination of domperidone along with sodium methylparaben, sodium propylparaben and sodium benzoate in liquid oral formulation. The chromatographic separations we...

Patel A.a, Firke S. D.*b, Patil R. R.b,

Kalaskar M. G.b, Bari S. B.a and Surana S. J.b,

Formulation and Evaluation of Fast Dissolving Tablets of Loratadine Solid Dispersion Using Super disintegrants

PAGE 84-87

The aim of the present investigation was to prepare solid dispersion (SD) of the water insoluble drug. Loratadine using super disintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. The SD’s of the drug...

Kumar S.a, Kumar J. V.a and Singhal P.b*

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