Table of Contents

January  2020

  • Volume 57
  • Issue 1
  • Page Nos. 78

Guest Editorial

A CLARION CALL TO ALL INDIANS TO FACILITATE INTENSE RESEARCH ON NATURAL PRODUCTS

PAGE 5-6

Dr. Gopakumar G. Nair is a Ph.D in Organic Chemistry (1966) from National Chemical Laboratory Pune (Pune University). He was a Post-Doctoral fellow at IIT Bombay, Powai (1967) before joining the Pharma Industry. He was Director of Bombay Drug House P. Ltd., later Chairman of BDH Industries Ltd. a...

Dr. Gopakumar G. Nair
Editor,
Indian Drugs

Review Article

HYDROPHOBIC ION-PAIRED DRUG DELIVERY SYSTEM: A REVIEW

PAGE 7-18

Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase. This could affect a higher permeation through biological membranes. HIP comple...

Abu Hajleh Mahaa,b* and Al-Dujaili Emad A.S.c

Original Research Articles

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIPERAZINE ANALOGUES CONTAINING [1, 3, 4]-OXADIAZOLE RING

PAGE 19-26

A new series of piperazine-1, 3, 4-oxadiazole deviatives were synthesized by the condensation of 1, 3, 4-thidaizole with substituted piperazine, in the presence of N, N-diisopropylethylamine. The structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectroscopy. All the precursors were scree...

Kottakki Naveen Kumara, P V D Soujanya Kumarib, G Gopib, Amperayani Karteek Raoc, Parimiuma Devic*.

In vitro Evaluation for Protective Effect of Bamboo Leaves Against Gamma Radiation Induced Genetic Damage and Their Polyphenols Quantification Using RP-HPLC

PAGE 27-36

Radioprotector is the prime antidote to radiation injury. The desire to search an ideal radioprotector led us to explore natural sources. Bamboo species are known for theirimmense medicinal potential such as antioxidant, anti-inflammatory, anti-cancer, immunomodulatory activities and are enriched...

Patel Mansia, Tewari Shikhab, Bhayani Dharaa, Bakshi Sonalb, Patel Snehala and Priti Mehtaa*

Synthesis and Characterization of Thiolated Gum Kondagogu and Evaluation as Mucoadhesive Polymer

PAGE 37-43

Present work focused on thiolation for enhancing the mucoadhesive potential of Gum kondagogu (GK). Thiolation of GK was done by esterification process with 80 % thioglycolic acid in presence of 7N HCl. Thiolated Gum kondagogu (ThioGK) was determined to possess 1.59 ±0.04 mmol of thiol groups/g o...

Patil Ashwin A.a, Patil Ketan B.a and Zawar Laxmikant R.a*

STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF EMTRICITABINE, BICTEGRAVIR AND TENOFOVIR ALAFeNAMIDE

PAGE 44-50

A simple, specific, precise and robust method for the estimation of emtricitabine, bictegravir and tenofovir alafenamide in the presence of impurities was developed and validated. The separation was performed on Aquity UPLC system with SB C8 50 x 2.1 mm, 1.7μ column under isocratic elution mode....

K Pushpa Kumaria* and D Gowri Sankara

Simple, cost effective UV-VIS method for estimation of Elvitegravir (EVG) in pure and dosage form by QbD approach and in presence of mammalian plasma

PAGE 51-58

A simple, cost effective, UV-VIS spectrophotometric method for analysis of elvitegravir (EVG) in the presence of plasma was developed to facilitate the assessment of clinical samples or as a routine alternative tool in drug quality control laboratories for quantitative estimation of EVG. The pres...

Ghante Minal R.a*, Masale Akash C.a, Jagtap Supriya G.a, Sawant Sanjay D.a and Nikam Vandana S.a

Biosynthesis and Development of Novel Method for Commercial Production of Biosurfactant utilizing waste potato peels

PAGE 59-65

The aim of this research work was to create compelling strategy for biosurfactant generation by waste potato peels and pulp utilizing mutated B.subtilis DDU20161. Major parameters like creation of medium, fomentation, and pH were kept up in the investigation. The ideal biosurfactant yield by acet...

Pande Vishala, Patel Vipula*, Salunke Priyankab and Patel Unnatic

Metformin prevents phenytoin induced cognitive impairment

PAGE 66-71

Cognitive impairment is one of the major problems associated with antiepileptic drugs. Phenytoin is one of the widely used anticonvulsant drugs, but it adversely affects learning and memory on prolonged use due to generation of reactive oxygen species. Metformin promotes neurogenesis, enhances sp...

Tiwari Prashanta, Patel Nirjharinib, Jena Susmitab, Prusty Shakti Ketanb and Sahu Pratap Kumarb

Short Notes

EFFECT OF SOLVENTS IN CHROMATOGRAPHIC DETERMINATION OF SILDENAFIL CITRATE IN MARKETED FORMULATION

PAGE 72-75

Chromatography is the procedure for analysing a multicomponent mixture of trace, minor or major constituent by separaationinto its individual fractions.For the analytical determination of sildenafil in pharmaceutical dosages forms an expeditious & sensitive RP-HPLC method is described.The mob...

Choudhury Priyabatia*, Roy Smritia,Adhikari Lopamudrab and Pattanaik Sovanb

Essential Oil Composition and GCMS Analysis of Tanacetum pinnatum Boiss Populations in Iran

PAGE 76-79

The genus Tanacetum L. belongs to the Asteraceae family and is one of the most important medicinal group that contains 26 species in Iran, 12 of them being endemic. Tanacetum pinnatum Boiss. grows wild in Iran. This paper reports the essential oil composition of T. pinnatum population in 3 provin...

Fatemehalsadat Serria, Mohammad bagher Rezaeab*, Abbas Ghamarizareb, Hassanali Naghdi Badic and Ali Mehrafarinc

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