Table of Contents

July  2020

  • Volume 57
  • Issue 7
  • Page Nos. 84

Guest Editorial

Spices, COVID-19 and Low hanging fruits for the Pharmaceutical Industry

PAGE 5-6

Dr D B Anantha Narayana, is the Chief Scientific Officer, AYURVIDYE TRUST, Bangalore. He Championed the Notifications of Supplements and Nutraceuticals Regulations, FSSAI, 2016 Updated in 2017 and Phytopharmaceuticals as Drugs under Drugs & Cosmetics Act & rules, 2016. He is a recipient o...

Dr D B Anantha Narayana

Bengaluru

Review Article

EMERGENCE OF BENZOTHIAZOLE AND ITS DERIVATIVES AS A POTENTIAL ANTIDIABETIC PROBE

PAGE 7-18

Development of drugs against diabetes has always remained a big challenge among the medicinal chemists around the globe because of its continuously increasing prevalence worldwide. The emergence of benzothiazole as a prominent lead against diabetes is credited to the development of the aldose red...

Neeraj Bainsala *, Jitender Singha and Aman Thakurb

Original Research Articles

DESIGN AND SYNTHESIS OF NOVEL TRIAZOLYL/OXADIAZOLYL/ THIADIAZOLYL-CARBAZOLES AS POTENT ANTICONVULSANT AGENTS

PAGE 19-25

Compound-1, was synthesized by the reaction of carbazole with chloroacetyl chloride in dry acetone. Compound 1 on reaction with hydrazine hydrate yielded compound 2, which on reaction with various substituted phenyl isothiocyanates in absolute alcohol yielded compounds 3-8 i.e.2-(carbazolylacetyl...

Archanaa* and Chaudhary S.a

LEAD IDENTIFICATION OF HYDROXAMATE DERIVATIVE AS SELECTIVE HDAC2 INHIBITOR USING COMPUTATIONAL APPROACHES

PAGE 26-39

Histone deacetylase (HDAC) inhibitors have been established as a novel class of anticancer agents. The HDAC enzyme plays a vital role in gene transcription for regulation of cell proliferation, migration and apoptosis, immune pathways and angiogenesis. In this work, a series of 49 hydroxamate der...

Divya, Shirbhate E.a , Patel V.K.a , Patel P.a , Veerasamy R.b, Jawaid T.c , Kamal M.d and Rajak H.a *

RP-HPLC AND HPTLC METHODS FOR THE ESTIMATION OF LUPEOL IN. HEMIDESMUS INDICUS LINN. ROOT EXTRACTS AND POLYHERBAL FORMULATION USING STANDARD MA

PAGE 40-46

The roots of Hemidesmus indicus, belonging to the family Ascelpidaceae, are used as blood purifier, antileucorrhoeic, galactogenic, antidiarrhoeal, antirheumatic, antisyphilitic, febrifuge and possesses chemical constituents like triterpenoids (lupeol), flavonoids, glycosides and tannins. Roots w...

Rajendran Jayaprakasama , Chacko Anita Elizabetha , Thomas Tresaa , Johnson Neethua and Thengungal Kochupapy Ravia

DEVELOPMENT AND VALIDATION OFRP-HPLC METHOD FOR ESTIMATION OF EDOXABAN TOSYLATE IN TABLET DOSAGE FORMS

PAGE 47-51

A rapid, simple and precise reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the estimation of edoxabantosylate in tablets. The quantification was carried out using a Phenomenex C-18 column (250×4.6 mm i.d., 5µm particle size) in isocratic mode with mobil...

B. Anupama*a , P. Tejaswia , KNV. Chenchu Lakshmia and A. Vishwanadhb

DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES OF NICERGOLINE FOR BUCCAL DRUG DELIVERY BY USING FACTORIAL DESIGN OF EXPERIMENT (DOE)

PAGE 52-57

The aim of this research was to develop mucoadhesive buccal patches of nicergoline by using Factorial Design of Experiment, in order to provide a sustained release of drug into the systemic circulation. A 33 factorial experimental design was employed for optimization and to study the effect of fo...

Sagara , Sethi V. A. a, and Tyagi L. K. a*

WOUND HEALING ACTIVITY OF AERIAL PARTS OF eUPHORBIA HIrTA LINN. AND ITS POLYHERBAL FORMULATION

PAGE 58-62

This study was undertaken to investigate the in vivo wound healing activity of ethanol extracts of the aerial parts of Euphorbia hirta Linn. and its polyherbal formulation with Tridax procumbens and Eclipta alba. The in vivo wound healing activity was assessed in albino rats by using three wound ...

Pushpendra Kumar Jaina , Yogesh Pounikara and Navneet Khuranab

NEPHROPROTECTIVE EFFECT OF TUKHME KARAFS (APIUM GRAVEOLENS L.) AGAINST GENTAMICIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL ANIMALS

PAGE 63-69

Tukhme Karafs is the seed of Apium graveolens L., which is an important aromatic plant grown globally as a fresh herb and widely used as salad crop. This seed possesses potential pharmacological activity like hepatoprotective, diuretic and lithotriptic. The present study was designed to evaluate ...

Mohd Naushada , Mohd Uroojb, Tasleem Ahmedc , Gulam Mohammed Husaind, Munawwar Husain Kazmia , Ghazala Javede and Mohammad Zakirf*

Short Notes

IMPROVEMENT OF WATER SOLUBILITY AND IN vITrO DISSOLUTION RATE OF DEFLAZACORT BY COMPLEXATION WITH β-CYCLODEXTRIN THROUGH FREEZE DRYING PROCESS

PAGE 70-76

Deflazacort is a poorly water-soluble drug and is practically insoluble in water. The objective of this study was to improve the solubility of deflazacort by using as solubility enhancer β-cyclodextrin and also to study the effect of the water-soluble polymer PEG 4000 on solubility of the deflaz...

Dkhar Gatphoha , M.Vijay Kumara and B.C. Revanasiddappaa*

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