Table of Contents

August  2020

  • Volume 57
  • Issue 8
  • Page Nos. 86

Guest Editorial

Research and Patenting in COVID Times

PAGE 5-6

Dr. Gopakumar G. Nair is a Ph.D in Organic Chemistry (1966) from National Chemical Laboratory, Pune (Pune University). He was a Post-Doctoral fellow at IIT Bombay, Powai (1967) before joining the Pharma Industry. He was Director of Bombay Drug House P. Ltd., later Chairman of BDH Industries Ltd. ...

Dr. Gopakumar G. Nair

Editor,

Indian Drugs

Review Article

LIPID PEROXIDATION A PARAMETER LINKED TO OXIDATIVE STRESS AND PSORIASIS: A REVIEW

PAGE 7-15

Psoriasis is a chronic inflammatory skin disease resulting in red silvery skin patches, increased dermal vascularity and keratinocyte hyper proliferation, particularly on extensor prominences and the scalp. There are some exogenous chemicals and endogenous sources which causes skin dysfunction du...

Hina Chadhaa*, Phoolchandraa and Bibekanand Mehera

Original Research Articles

Docking Study of Novel N-substituted 2,5-Bis[(7-chloroquinolin-4-yl)amino]pentanoic Derivatives as Selective High-binder with Angiotensin Converting Enzyme 2

PAGE 16-24

The prevalence of a novel coronavirus (2019-nCoV) in the last few months represents a serious threat as a world health emergency concern. Angiotensin-converting enzyme 2 (ACE2) is the host cellular receptor for the respiratory syndrome of coronavirus epidemic in 2019 (2019-nCoV). In this work, th...

Mohammed Oday Ezzata , Basma M. Abd Razikb and Kutayba F. Dawoodc

SYNTHESIS OF SILVER NANOPARTICLES USING AQUEOUS EXTRACT OF PERGULARIA DAEMIA AND ANALYSIS OF ANTIMICROBIAL ACTIVITY

PAGE 25-29

The present work deals with the green synthesis of silver nanoparticle from aqueous extract of Pergularia daemia as reducing agent and evaluation of the antimicrobial potential of synthesized green nanoparticles (GNPs). The synthesized silver nanoparticles (SNPs) were characterized by Ultraviolet...

Kadam Jambuwant A.a*, Karale Mahesh A.b and Karale Pushpac

SPECTROPHOTOMETRIC AND HPTLC STUDIES ON SELECTED INDIAN SPICE EXTRACTS

PAGE 30-34

The present work was carried out with a view to analyze the major phytochemical compounds of Indian spices, dalchini (Cinnamon zeylanicum) bark and coriander (Coriander sativum) fruit. Hydro-alcoholic extracts were prepared from selected spices and analyzed for extract yield, loss on drying (LOD)...

Soni P.a , Soni V. a* and Sharma P. a

UV Spectrophotometric Methods for Determination of Palbociclib in Bulk and In-house Capsule Formulation

PAGE 35-40

Four different simple, accurate and precise UV-spectrophotometric methods have been developed for the estimation of palbociclib (PB) in bulk and in-house capsule dosage form by zero order (Method I), zero order AUC (Method II), ‘first order derivative UV-spectrophotometric (Method III), and fir...

Rathod Rahul D.a , Mundada Anand B.a*, Patel Harun M.a and Shirkhedkar Atul A.a

Quality by Design Approach (QbD) for the Simultaneous Estimation of Candesartan Cilexetil and Amlodipine Besylate by RP–HPLC

PAGE 41-52

A revers phase liquid chromatographic technique has been developed for the separation and determination of candesartan cilexetil and amlodipine besylate using QbD (Quality by Design) approach. The present method was optimised by introducing experimental design approach to identify the chromatogra...

Kamli Ankita*, Shah Megha and Hinge Madhuri

Development and evaluation of Ziprasidone Loaded Solid Self-Micro Emulsifying Drug Delivery System

PAGE 53-60

Solid self-micro emulsification technique is the new approach for poorly water-soluble and poorly bioavailable drugs by allowing the drug substance to be incorporated into the oil phase and thus having the ability to permeate the GI membrane to a faster extent. Oleic acid, Tween 80, methanol and ...

Patil Purushottama*, Shaikh Malika and Mahaparale Paresha

Green synthesis of gold nanoparticles of isolated citrus bioflavonoid from orange: Characterization and in vitro cytotoxicity against colon cancer cell lines COLO 320DM and HT29

PAGE 61-69

The aim of the present research was to perform green synthesis of gold nanoparticles of isolated citrus bioflavonoid from Citrus sinensis (orange) peel extract and to evaluate its anticancer potential. Methanolic extract of orange peel was obtained by Soxhlet extraction and citrus bioflavonoid wa...

Randive D. S.a , Shejawal K. P. a, Bhinge S. D.a , Bhutkar M. A. a., Patil P. D. a, Jadhav N. R.b and Patil S. B.c

Short Notes

A validated stability indicating RP-HPLC method for determination of Azelnidipine and its impurities in Pharmaceutical Formulation

PAGE 70-76

A novel simple, rapid, sensitive and stability-indicating RP-HPLC method was developed and validated for the determination of azelnidipine (ALDP) and its impurities 1 and 2. Resolution of drug, its potential impurities and degradation products were achieved by RP-HPLC on was performed on Prontosi...

Pavani Peddia*, S. L. Tulasia , N.Usha Rania and T. Raja Rajeswaric

NATEGLINIDE SILICA LIPID HYBRID PARTICLES FOR IMPROVED SOLUBILITY

PAGE 77-81

Porous silica-based drug delivery systems have shown substantial potential for improving the oral delivery of poorly water-soluble drugs. The major problem with nateglinide, a BCS Class II drug, is pH-dependent solubility, limited aqueous solubility, poor dissolution and variable bioavailability....

Tiwari Shradhaa , Wadher Shaileshb and Gattani Surendrac

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