Table of Contents

November  2023

  • Volume 60
  • Issue 11
  • Page Nos. 92

Guest Editorial

OMEGA-3 – ONLY VIRTUALLY BENEFICIAL FOR THE VEGANS & FANATIC VEGETARIANS!

PAGE 5-6

Dear Reader,

Dinner table conversations revolve around food, travel, politics and now, increasingly, health and nutrition – post the COVID-19 surge. Amongst the conditions commonly discussed, products for immunity, diabetes and heart disease take precedence. Besides immune builders, ome...

Dr R K Sanghavi

Consultant - NeuroMarketing & TechnoRegulatory (Pharma & Nutra)

Chairman – Nutraceutical Committee (IDMA)

Review Article

CHALLENGES AND OPPORTUNITIES WITH DRUG REPURPOSING: AN EMERGING TECHNIQUE IN DRUGS DISCOVERY

PAGE 7-18

The term “drug repurposing” refers to the practice of identifying unmet medical needs and developing innovative solutions using already available drugs. It’s a useful strategy for identifying or developing new medicinal molecules with untapped therapeutic potential. Some of the computationa...

Sanyogita Haralea *, Pooja Huparea , Prajakta Ghatagea , Vijaya Govandea , Omkar Gurava , Sandip Bandgara , Sachin Patila and Dinanath Gaikwadb

Original Research Articles

SYNTHESIS, STRUCTURAL CHARACTERIZATION AND SOLUBILITY INVESTIGATION OF FLURBIPROFEN ISOBUTANOL AMMONIUM SALT

PAGE 19-27

This research is centered on the conversion of active pharmaceutical ingredients (APIs) into salt formulations, aiming to enhance their solubility, improve absorption into the bloodstream, and ultimately elevate their therapeutic effectiveness. More specifically, it delves into the synthesis and ...

Vaibhavi P. Thakura , Pritam V. Bagwea , Prashant S. Kharkarand Shreerang V. Joshia *

DEVELOPMENT OF ERLOTINIB ENCAPSULATED SELF-ASSEMBLED MIXED MICELLES: OPTIMIZATION AND IN VITRO EVALUATION

PAGE 28-35

For the treatment of lung cancer, erlotinib is used as primary treatment. Erlotinib is an epidermal growth factor receptor inhibitor, however it is deposited in normal cells also and clinicians do not prefer it. This constraint opens the way for development of targeted therapy. Mixed micelles via...

Shruti Patela and Asha Patela *

FORMULATION OF VITEX NEGUNDO ETHOSOMAL LOADED TOPICAL HERBAL GEL AND ITS EVALUATION FOR ARTHRITIS TREATMENT

PAGE 36-42

The current research aims to develop and test a system of vesicular drug carriers for topical drug administration of Vitex negundo Linn. to provide sustained drug delivery. The ethosomes of V. negundo Linn. were produced using thin-film hydration, and their in vitro drug release profiles, size, d...

Pratiksha S. Dhembarea *, Priyanka G. Kusarkara , Archana S. Murgundea , Trupti P. Ladea and Sandeep R. Kanea

COMPARATIVE ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ETHANOL EXTRACTS OF THE GENUS MONARDA REPRESENTATIVES ON THE EXAMPLE OF DROSOPHILA MELANOGASTER

PAGE 43-50

Determination of toxic, genotoxic and cytotoxic effects of Drosophila melanogaster for Monarda fistulosa var. menthifolia, M. fistulosa, M. didyma and M. media was carried out. The Oregon-R line was used to test for toxic manifestations in a number of indicators: fecundity, earl...

Olga N. Antosyuka *, Elizaveta V. Bolotnikb and Irina A. Sakovaa

A NOVEL STABILITY INDICATING UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND CHLORTHALIDONE IN ITS PURE AND PHARMACEUTICAL DOSAGE FORM

PAGE 51-58

An accurate, precise and simple stability indicating ultraviolet spectroscopic technique was developed to quantify azelnidipine and chlorthalidone, simultaneously was bulk and in combination by absorbance correction method. Ethanol (99.9 %) is used as the solvent in the method. The detection wave...

Swapna A. Surendrana , Haribabu Y.a , Sheeja V. Kuttya , Sreelekha P. Pavithrana * and Niranjana C. Muralidharana

FORCED DEGRADATION STUDIES OF VINCAMINE BY HPTLC

PAGE 59-62

Vincamine is an alkaloid with vasodilator properties. Vinpocetine, a semi-synthetic vincamine derivative alkaloid, is used to treat cerebrovascular diseases like stroke and dementia. Being an important molecule, the current research work examines the forced degradation studies of vincamine using ...

Christina V. Johna and Aruna P. Jadhava *

STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR CERITINIB IN BULK AND FORMULATION

PAGE 63-69

Ceritinib is an anti-cancer of drug used in treatment of non-small cell lung cancer. A high-performance thin layer chromatography (HPTLC) method has been developed for ceritinib, which is stability indicating and simple, precise, and discriminating. The stationary phase used was aluminum-backed s...

Santosh V. Gandhia *, Shivani R. Sawarkara and Mrinalini C. Damlea

EXPLORATION OF MECHANISM OF HYGROPHILA AURICULATA TO TREAT CARBOPLATIN INDUCED TOXICITIES BUILT ON NETWORK PHARMACOLOGY

PAGE 70-81

Hygrophila auriculata is a traditional herb used for several ailments, with an unclear mechanism of action. The present study aimed to detect its efficacy on nephrotoxicity and hepatotoxicity in Wistar rats followed by network pharmacology analysis to explain its mechanism of action. 24 rats were...

Arpita Chakrabortya , Reena S. Parveena , Sangita G. Kamatha *, Veena Nayaka , Suchetha P. Kumarb and Vijetha Shenoy Bellec

Short Communications

ANALYTICAL UV SPECTROSCOPY METHOD DEVELOPMENT AND VALIDATION STUDIES FOR SIMULTANEOUS ESTIMATION OF METFORMIN HCL AND QUERCETIN

PAGE 82-87

In the current investigation, we have designed and assessed a simple and swift analytical approach employing UV spectroscopy for the simultaneous quantification of the analytes metformin and quercetin with excellent precision and accuracy. The wavelengths of interest are the wavelengths at which ...

Rushikesh Malia and Tabassum Khanb*

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