Table of Contents

January  2024

  • Volume 61
  • Issue 1
  • Page Nos. 96

Guest Editorial

LIVING WITH THE GHOST: CAN WE EVER ESCAPE COVID-19’S SHADOW?

PAGE 5-6

Dear Reader,

A strange virus flipped our world upside down, two and a half years ago, making us feel like we were living in a science-fiction film. Lockdowns, masks, and social isolation were all terms we had to learn. Uncertainty reigned supreme and terror became our constant companion. ...

Prof. (Dr.) Pooja A Chawla

University Institute of Pharmaceutical Sciences and Research

Baba Farid University of Health Sciences,

Faridkot, Punjab, India.

Review Article

TECHNIQUES AND ALGORITHMS FOR STRUCTURE-BASED VIRTUAL SCREENING (SBVS): AN OVERVIEW

PAGE 7-17

Today, the world of science is constantly challenged with new genomics, which in turn is responsible for new disease-causing targets. Hence, there is a need for developing drugs acting against such targets. Computational methods are proving to be a mainstay in the drug discovery process, mainly t...

Raksha K. Raoa *, Somdatta Y. Chaudharia , Shailaja B. Jadhava , Pravin D. Chaudharib and Ujwala B. Yedakea

Original Research Articles

MOLECULAR FIELD ANALYSIS AND DYNAMIC SIMULATION STUDIES OF 1,5-DISUBSTITUTED PYRAZOLINE-BASED MAO-A INHIBITORS FOR THE MANAGEMENT OF DEPRESSION

PAGE 18-37

Depression, along with grief and anxiety, is currently one of the most common mental illnesses. It was placed 25th among the major diseases. QSAR (CoMFA) of 37 compounds with MAO-A inhibitory activity yielded the most significant QSAR model, m.3, with r2 = 0.963, SDEC= 0.129...

Abhimannu Shomea , Pooja A. Chawlaa *, Naresh K. Rangraa , Volkan Eyupoglub and Ravi Rawatc

DIALKYL ISOMERS OF BENZENESULFONAMIDPHENYLPYRIMIDINE-4(1H)-ONE: SYNTHESIS, STRUCTURE AND PHARMACOLOGICAL STUDIES

PAGE 38-45

Interaction of N-acetyl-2-phenylacetamide with sulfanilamide and N-(2-phenylacetyl)propanamide with sulfanilamide led to the preparation of the two isomeric benzenesulfonamidphenylpyrimidin-4(1H)-ones. In positions 2 and 6, the synthesized phenylpyrimidin-4(1H)-ones contained methyl and ethyl as ...

Denis S. Anenkoa *, Ivan P. Kodonidib, Sergey D. Kirikc,d, Tamara N. Glizhovaa and Narzullo B. Saidove

OPTIMIZATION AND CHARACTERIZATION OF FAST DISSOLVING TABLETS OF CANDESARTAN CILEXETIL PREPARED FROM SPHERICAL AGGLOMERATES

PAGE 46-52

The primary objective of this study was to develop a rapidly dissolving tablet containing an antihypertensive drug, candesartan cilexetil (CAND). The research work focused on improving solubility and in vitro dissolution of drugs using spherical agglomeration technique. Spherical agglomerates of ...

Swapnil S. Patila *, Rohan D. Patila , Prakash V. Chavana , Nisha M. Jagtapb, Harshad P. Khadeb, Shashikant S. Upadhyeb, Suraj J. Patilb and Sandip M. Honmanea

FORMULATION AND DEVELOPMENT OF BIOADHESIVE PELLETS FOR MANAGEMENT OF HELICOBACTER PYLORI INFECTION

PAGE 53-60

Helicobacter pylori, a gram-negative bacterium, is a group I carcinogen which is responsible for duodenal ulcer, gastric ulcer, and gastric cancer. The existing treatment is based on the use of proton pump inhibitors, but is inadequate owing to factors such as low concentration of drug reaching t...

Raj Khatria , Munira Momina *, Sankalp Gharata and Mansi Damania

INVESTIGATION OF THE HEPATOPROTECTIVE POTENTIAL OF FRACTIONS AND PHYTOSOMAL COMPLEXES OF TELFAIRIA OCCIDENTALIS HOOK F LEAF EXTRACTS ON ALCOHOL-INDUCED HEPATOTOXICITY IN RAT MODELS

PAGE 61-69

The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. ...

Romanus C. Omeha *, Kenneth O. Okolob, Mercy E. Ugwuezea , Chukwuemeka C Mbahc , Anthony A. Atammad, Mumuni A. Momohd, Josephat I. Ogbonnac and Lydia O. Ugorjic

EVALUATION OF IN VITRO CYTOTOXIC POTENTIAL OF DIFFERENT CARMUSTINE FORMULATIONS AGAINST U-87 MG HUMAN GLIOBLASTOMA CELL LINE

PAGE 70-76

Glioblastoma (GBM) is a frequent as well as violent type of brain tumor. In this research work, different carmustine formulations were prepared and screened for their cytotoxic activity against U-87 MG glioblastoma and normal human fibroblast L-929 cell lines. The flexible liposomes embedded in s...

Audumbar D. Malia * and Anil S. Bhanwaseb

ENHANCING GASTRIC ULCER MANAGEMENT: NOVEL INSIGHTS FROM TERAZOSIN-PANTOPRAZOLE COMBINATION THERAPY

PAGE 77-85

In this present study, we explored a novel approach to gastric ulcer management by investigating the therapeutic potential of terazosin, an alpha-1 adrenergic receptor inhibitor, in combination with pantoprazole, a common anti-ulcer agent. Employing an ethanol-induced rat-gastric ulcer model, the...

Teresa J. Vadakutta and Gaurav M. Doshia *

Short Communications

FORMULATION AND ASSESSMENT OF A SUNSCREEN CREAM BASED ON GREEN TEA AND MARIGOLD FLOWER EXTRACTS

PAGE 86-88

This study focuses on in vitro screening of aqueous and ethanolic extracts from green tea leaves and marigold petals for anti-solar potential using UV method. Ethanolic extracts were prepared via maceration, and evaluated for SPF. UV-1700 spectrometer was used to assess SPF and readings were aver...

Akshay V. Rasala , Amol Kumar A. Kempwadea * and Madhuri Sankpala

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