Article Details

DEVELOPMENT AND VALIDATION OFRP-HPLC METHOD FOR ESTIMATION OF EDOXABAN TOSYLATE IN TABLET DOSAGE FORMS

B. Anupama*a , P. Tejaswia , KNV. Chenchu Lakshmia and A. Vishwanadhb

aKVSR Siddhartha college of pharmaceutical sciences, Vijayawada - 520 010, Andhra Pradhesh, India

bVignan college of pharmacy, Guntur - 522 213, Andhra Pradhesh, India

*For Correspondence E-mail: anurochi8@gmail.com


ABSTRACT

A rapid, simple and precise reversed phase high performance liquid chromatography (RP-HPLC) method was developed for the estimation of edoxabantosylate in tablets. The quantification was carried out using a Phenomenex C-18 column (250×4.6 mm i.d., 5µm particle size) in isocratic mode with mobile phase comprising of ammonium acetate buffer andacetonitrile in the ratio of 50:50 (V/V) at a flow rate 1 mL/min. The eluent was monitored at 240 nm. The retention time of the drug was 3.486 min. The calibration curve was linear in the concentration range of 5-25 µg/mL and per cent recovery ranged from 98.25-101.6.The developed method was validated as per ICH guidelines and the results obtained were satisfactory.The method can be applied for routine quality control analysis of edoxabantosylate in tablet dosage forms

Year 2020 | Volume No. 57 | Issue No.7 | Page No. 47-51
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