Article Details

IMPROVEMENT OF WATER SOLUBILITY AND IN VITRO DISSOLUTION RATE OF DEFLAZACORT BY COMPLEXATION WITH β-CYCLODEXTRIN THROUGH FREEZE DRYING PROCESS

Kulkarni Nilesh S.a*, Gitte Pallavi D.a, Munde Manojkumar K.a and Dhole Shashikant N.a

Department of Pharmaceutics, PES Modern College of Pharmacy (for Ladies), Moshi, Pune, 412 105, Maharashtra, India.

*For Correspondence E-mail: nileshpcist@gmail.com


ABSTRACT

Deflazacort is a poorly water-soluble drug and is practically insoluble in water. The objective of this study was to improve the solubility of deflazacort by using as solubility enhancer β-cyclodextrin and also to study the effect of the water-soluble polymer PEG 4000 on solubility of the deflazacort:β-cyclodextrin binary system. The inclusion complexes of deflazacort with β-cyclodextrin in 1:1 w/w, 1:2 w/w and 1:3 w/w proportions were prepared by kneading, microwave irradiation and freeze-drying techniques. The in vitro dissolution study showed improved dissolution rate for deflazacort for freeze-dried binary deflazacort: β-cyclodextrin 1:2 w/w complex, as compared to ternary deflazacort:β-cyclodextrin: PEG 6000 1:2 w/w complexes, plain deflazacort, physical mixtures and complexes prepared by kneading and microwave technique. This was confirmed by Fourier transform infrared spectroscopy, differential scanning calorimetry, powder x-ray diffraction study, scanning electron microscopy and 1 H nuclear magnetic resonance spectroscopy study. Thus, deflazacort:β-cyclodextrin complex with improved solubility was successfully developed using freeze drying technique.

Year 2020 | Volume No. 57 | Issue No.7 | Page No. 70-73
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