Article Details


Abu Hajleh Mahaa,b* and Al-Dujaili Emad A.S.c

a Faculty of Pharmacy, The University of Jordan, Amman, Jordan, Post code: Jordan – 11942.

b Department of Pharmacy, Middle East University, Amman, Jordan. Post code: Jordan – 11610.

c Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland, UK

*For Correspondence:


Hydrophobic ion-pairing (HIP) complexation technique has been displayed to modify the physicochemical properties, solubility, oral absorption, bioavailability, and the lipophilicity of an ionic drug in the lipid phase. This could affect a higher permeation through biological membranes. HIP complexation was considered through the formation of a neutral molecule by electrostatic interaction of ionizable groups of drugs with oppositely charged functional groups of a complex-forming agent. Subsequently, this ion-pair may encapsulate into many delivery systems. The objective of this manuscript was to study the effectiveness of ion-pair complextion and cover the update application of this strategy through several routes of administration such as ocular, oral, pulmonary, transdermal, and parenteral.

Year 2020 | Volume No. 57 | Issue No.1 | Page No. 7-18
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