Article Details

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIPERAZINE ANALOGUES CONTAINING [1, 3, 4]-OXADIAZOLE RING

Kottakki Naveen Kumara, P V D Soujanya Kumarib, G Gopib, Amperayani Karteek Raoc, Parimiuma Devic*.

a Department of Chemistry, GITAM University, Visakhapatnam - 530 045, Andhra Pradesh, India

b Department of Microbiology, M.V.R Degree and PG College, Visakhapatnam - 530 026, Andhra Pradesh, India

c Department of Chemistry, GVP Degree and PG College, Visakhapatnam - 530 026, Andhra Pradesh, India

*For Correspondence: umadevichemistry@gmail.com


ABSTRACT

A new series of piperazine-1, 3, 4-oxadiazole deviatives were synthesized by the condensation of 1, 3, 4-thidaizole with substituted piperazine, in the presence of N, N-diisopropylethylamine. The structures were confirmed by IR, 1H NMR, 13C NMR and Mass spectroscopy. All the precursors were screened for anti-bacterial activity and the results indicate that phenyl substituted chloro (PO2) and hydroxy (PO6) functional derivatives possess better anti-bacterial activity towards to Gram-positive bacteria and gram-negative bacteria, Maximum zone of inhibition was observed in (PO2) against Bacillus subtillus (14.0 mm) and (PO6) against Pseudomonas aeruginosa (14.0 mm). Piperazine-1, 3, 4-oxadiazoles were synthesized by combining two active molecules into a new bioactive conjugate molecule. These new hybrid molecules have more potential biological activity than their parent molecules.

Year 2020 | Volume No. 57 | Issue No.1 | Page No. 19-26
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