Article Details

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

T.C.Aishwaryaa, Jainey Jamesa, M.Vijay Kumara and B.C. Revanasiddappaa*

a Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte -Deemed to be University, Paneer, Deralakatte, Mangalore-575 018, Karnataka, India

* For Correspondence: E-mail: revan@nitte.edu.in


ABSTRACT

2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(5-aryl-1,3,4-oxadiazol2-yl)-2h-chromen-2-ones (2a-h). All the synthesized compounds were assigned structures on the basis of IR, 1 H-NMR and Mass spectral data. Some of the selected compounds were evaluated for In vivo anticonvulsant activity by MES and PTZ models.

Year 2020 | Volume No. 57 | Issue No.11 | Page No. 40-44
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