Article Details

Synthesis and Anti-diabetic Activity of Some Aryloxypropanolamine Derivatives

Puranik H. H.a, Jadhav S. B.a*, Bandawane D. D.b and Bhalekar P. A.a

a Department of Pharmaceutical Chemistry, PES’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune - 411 044, Maharashtra, India
b Department of Pharmacology, PES’s Modern College of Pharmacy, Yamunanagar, Nigdi, Pune - 411 044, Maharashtra, India
* For Correspondence: E-mail: sbjadhav_pharma@yahoo.co.in


ABSTRACT

Aryloxypropanolamine plays an important role in several biological activities. It shows multiple actions such as β-blocking, anxiolytic, antihypertensive and inhibition of cytochrome p450. A series of ten aryloxypropanolamine derivatives 6a–6j were synthesized and evaluated for anti-diabetic activity. Two compounds 6b to 6g have shown good anti-diabetic activity. All synthesized compounds (6a-6j) were evaluated for their anti-diabetic activity in STZ induced diabetes model of Wistar rats.

Year 2018 | Volume No. 55 | Issue No.10 | Page No. 16-23
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