Article Details

DESIGN, SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL BENZOTHIAZOLE BASED [1, 2, 4]-TRIAZOLO [4, 3-a] QUINOXALINE DERIVATIVES

Gadhave R. V.a*, and Kuchekar B. S.a

a Department of Pharmaceutical Chemistry, MAEER’s Maharashtra Institute of Pharmacy, MIT Campus, Kothrud, Pune - 411 038, Maharashtra, India

* For correspondence: E-mail: ranjitgadhave@gmail.com


ABSTRACT

Quinoxaline, triazole and benzothiazole heterocycles plays an important role in modulating biological activity. The present work describes the biological evaluation of target molecules designed using autodock vina docker. Novel benzothiazole based [1, 2, 4]-triazolo [4, 3-a] quinoxalines were synthesized by condensation of substituted 2-amino benzothiazoles and 4-chloro triazoloquinoxalines. The synthesized compounds were characterized by analysis of physical and spectral data. All synthesized compounds were screened for antioxidant activity using 1, 1-Diphenyl-2-picrylhyrazyl radical scavenging, Hydrogen peroxide scavenging and Ferric reducing antioxidant power Method. The compounds 10g and 10i were found to be most active compounds of this series and other compounds showed moderate to less activity when compared with ascorbic acid. Study revealed that the most active compounds after structural modifications can be exploited as lead molecules for other pharmacological activities such as antimicrobial, anti-inflammatory, anticancer and antidepressant, activity

Year 2019 | Volume No. 56 | Issue No.09 | Page No. 22-29
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