Article Details

Formulation and Evaluation of Fast Dissolving Tablets of Loratadine Solid Dispersion Using Super disintegrants

Kumar S.a, Kumar J. V.a and Singhal P.b*

a Department of Pharmaceutical Sciences, H.N.B. Garhwal (A Central) University, Srinagar Garhwal - 246 174, Uttarakhand, India

b* Department of Pharmaceutical Sciences, Gurukul Kangri Vishwavidyalaya, Haridwar - 249 404, Uttarakhand, India

*Corresponding author : E-mail: peeushpharma@gmail.com


ABSTRACT

The aim of the present investigation was to prepare solid dispersion (SD) of the water insoluble drug. Loratadine using super disintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. The SD’s of the drug were prepared by melt dispersion technique using polyethylene glycol (PEG) 6000 in diferent ratios 1 : 2.5, 1 : 5 and 1 : 7.5. The prepared SD formulations were characterized for equilibrium solubility, Fourier Transform Infrared spectroscopy (FTIR) and in vitro dissolution study. The batch containing SD formulation of loratadine showed fastest dissolution (99.87% drug release in 60 min). In this study, fast dissolving tablets were prepared by direct compression method using Croscarmellose sodium, sodium starch glycolate and polyplasdone XL as the super disintegrants. Effect of various super disintegrants on dissolution behavior of tablets was evaluated in phosphate buffer pH 6.8.

Year 2019 | Volume No. 56 | Issue No.08 | Page No. 84-87
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