Table of Contents

November  2020

  • Volume 57
  • Issue 11
  • Page Nos. 96

ISSN: 0019-462X (print)

Guest Editorial

NEED Of THE HOUR FOR INDIA - EVIDENCE-BASED ALL-INCLUSIVE PREVENTIVE NUTRA - NUTRI HOLISTIC APPROACH PRODUCTS BY BOTH PHARMA GIANTS AND CLUSTER STARTUPS

PAGE 5-6

Dear Reader,

This Guest Editorial could not have been better timed than now even though it should have given the call nearly ten years back! However, this editorial has become longer than what I envisaged, and seek your patience to read through it in your leisure time.

The positio...

Vish Prakash, Ph.D, FRSC

Former Director of CFTRI and former

Distinguished Scientist of CSIR

Mysore, India

Review Article

NATURAL PRODUCTS IN WOUND HEALING: NANO-TECHNOLOGY BASED APPROACHES

PAGE 7-14

Wound is a disruption of the normal anatomical structure and the tissue function. The wound healing or repair is an orderly process which involves multiple phases characterized by inflammation, proliferation and remodeling. Natural products, which are derived from herbs and animals, constitute se...

Kapare Harshad S.*a, Metkar Sarika R.a and Wakalkar Shweta V.a

Original Research Articles

COMPLEX Of ELUXADOLINE WITH SODIUM CAPRYLATE FOR IMPROvED SOLUBILITY AND DISSOLUTION RATE

PAGE 22-26

In the present research, newly developed complex with sodium caprylate was investigated for solubility and dissolution enhancement of eluxadoline. Complexes were prepared in different ratios by solvent evaporation method and characterised solubility study, Infrared spectroscopy (IR), Diffrential ...

Dhere Manishaa*, Majumdar Artia and Malviya Neelesha

VALIDATED STABILITY INDICATING UPLC METHOD FOR AFATINIB AND ITS IMPURITIES IN PHARMACEUTICAL DOSAGE FORM

PAGE 27-39

A novel, simple, selective, rapid stability-indicating and LC-MS compatible short run time UPLC method was developed and validated for the determination of afatinib and its related substances in bulk and finished dosage form. A reverse phase gradient mode short run time method has been developed ...

Ivaturi Ramu*a, T Manikya Sastryb and S Satyavenia

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

PAGE 40-44

2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(...

T.C.Aishwaryaa, Jainey Jamesa, M.Vijay Kumara and B.C. Revanasiddappaa*

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES OF GEMCITABINE NIOSOMES

PAGE 45-51

Gemcitabine hydrochloride niosomes were developed in our laboratory in an effort to improve the efficacy of the drug via development of nanotechnology based delivery system. As a part of this exercise, an analytical method was developed and validated to evaluate the developed formulation for assa...

Manjarekar Poojaa and Khan Tabassumb*

A NEW INVESTIGATIONAL METHOD FOR QUANTIFICATION AND VALIDATION OF ANALYTICAL METHOD FOR CEFIXIME AND ERDOSTEINE BY UPLC WITH PHOTO DIODE ARRAY DETECTOR IN BULK AND FORMULATION. APPLICATION TO THE ESTIMATION OF PRODUCT TRACES

PAGE 52-62

Specific and innovative method was developed and validated for the identification and quantification of cefixime and erdosteine in the bulk and formulation samples by UPLC with PDA detector.The analytical technique was with buffer (pH: 7.0): methanol, (65:35%, v/v) us...

Tammisetty Mohanraoa*, Challa balasekhara Reddyb and Puttagunta Srinivasa Babuc

SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN FIXED DOSE COMBINATION (FDC) BY Q-ABSORBANCE RATIO METHOD

PAGE 63-75

A simple Q-absorbance ratio method have been developed for the determination of dapagliflozin (DAPA) and saxagliptin (SAXA) in fixed dose combination (FDC) using UV-Visible spectrophotometer. In this method, the UV spectra of DAPA and SAXA were overlaid to obtain wavelength at isosbestic point (Î...

Gan Ee Howa and Bontha Venkata Subrahmanya Lokesh*a

Short Notes

ANTIOXIDANT, SEDATIVE AND HYPNOTIC POTENTIAL OF MILK EXTRACT OF MYRISTICA FRAGRANS: A COMPLIMENTARY MEDICINE FOR THE MANAGEMENT OF INSOMNIA

PAGE 76-82

The Myristica fragrans (MF) is well known in Ayurveda for many therapeutic uses. The present research work was carried out to investigate the antioxidant (in vitro), sedative and hypnotic effects of the MFmilk extracts in Wistar rats. The extraction was carried out by hot percolatio...

Raul Namitaa, Hatware Ketan Vinayakraoa*, Sharma Sanjaya ,Patil Kirana, Karri Sravania and Gautam Rupesh Kumarb

QUALITATIVE ANALYSIS OF CARICA PAPAYA LEAVES TABLET FORMULATION AND STUDY OF FRAGMENTATION PATTERN OF RUTIN

PAGE 83-86

The chemical constitution of Carica papaya leaves tablets and the fragmentation pattern of rutin is poorly investigated. Rutin was found to a constituent of tablet formulation. This work reports a study on the fragmentation pattern of rutin by electrospray ionization with multistage mass spectrom...

V. S. Tambea, A. M. Karnikb*, M.N. Deodharc, and Vijayalakshmi Prakyad

FORMULATION AND EVALUATION OF RUTIN TRIHYDRATE EMULGEL

PAGE 87-92

Emulgels (emulsion gels) are a class of biphasic semi-solid formulations, having aqueous and non-aqueous phases, delivering both hydrophilic and lipophilic agents. The main advantage of an emulgel is that lipophilic drugs can be easily formulated as emulgels. Rutin trihydrate is an herbal drug us...

Sushmitha C.a, Kusuma M.P.a* and Archana Ja

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