Table of Contents

January  2013

  • Volume 50
  • Issue 1
  • Page Nos. 1-72

Review Article

Cryptic Causes and Mechanisms involved in Ageing

Ageing is a natural process characterized by progressive deterioration of biological functions. Ageingcauses both morphological as well as biochemical alterations in various body organs leading todeterioration of health. Proteins, enzymes and neurotransmitters are affected, which in turn can resulti...
Challabotla K., Banji D., Banji O.J.F. and Reddy Chilipi K..

Original Research Articles

High-Performance Thin Layer Chromatographic Method for the SimultaneousQuantitation of Lopinavir and Ritonavir in Tablet Formulation

The present work describes a simple, accurate and precise HPTLC method for simultaneous quantitationof ritonavir (RVR) and lopinavir (LVR) in tablet formulation. Chromatographic separation of both drugswas performed on precoated aluminum plates, silica gel 60 F254 as the stationary phase and the sol...
Fegade J. D., Chawla N. D., Chaudhari R. Y. and Patil V. R.

Design, Development and Evaluation of Cationic Guar and Hydroxypropylguar BasedIn Situ Gels for Ophthalmic Drug Delivery

The poor bioavailability and therapeutic response exhibited by the conventional eye drops due to rapidcorneal loss is overcome by the use of ion-activated gel forming systems that are instilled as drops;these undergo gelation in cul-de-sac mode. The present study describes the design, development an...
Dasankoppa F.S. and Swamy N.G.N

Effect of Hydrophilic Polymers on Controlled Release Matrix Tablets of Acyclovir

Acyclovir was formulated as oral controlled release matrix tablets using natural and synthetic polymersseparately or in combinations. Tablets were prepared by direct compression method. The tablets wereevaluated to thickness, weight variation test, drug content, hardness, friability and in vitro rel...
Ashok Kumar P. and Damodar Kumar S.

Synthesis and Biological Evaluation of 2-SubstitutedPhenyl-1-(Substituted Piperazin-1-Yl) Methyl)-1H-Benzo[D]Imidazoles

A series of biologically active benzimidazole derivatives (2a-2n) was synthesized by the reaction ofo-phenylenediamine with the derivatives of benzoic acid in presence of 4N-HCl followed by the reactionwith piperazine and formaldehyde to undergo Mannich reaction. The structures of all the synthesize...
Gupta S. K., Kumar N., and Pathak D.

Short Notes

Development and Validation of Difference Spectroscopic Method for the Estimation ofTolperisone Hcl in Bulk and Pharmaceutical Dosage Form

Difference spectroscopic method is based on the principle that tolperisone hydrochloride can exhibit twodifferent absorption spectra in basic and acidic medium. A stock solution (1 mg/ml) was prepared withdistilled water. Further dilution was made by using 0.1 N sodium hydroxide and 0.1 N hydrochlor...
Gohil K., Shah B., Patel B., Patel P. and Patel N.

Analgesic and Anti-Inflammatory Activities of Ixora Coccinea Flower

The present study was an endeavor to evaluate anti-inflammatory and analgesic activity of methanolicextract of Ixora coccinea flowers (ICF-ME). The in vivo anti-inflammatory was evaluated in rats by usingcarageenan-induced paw edema, as an acute anti-inflammatory model. Quantitative estimation of to...
Aher A.N., Pal S. C. and Muke S. A..
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