ABSTRACT

Peristrophe bicalyculata posses expectorant, analgesic, anti-inflamatory, antipyretic and antibacterial properties and has been traditionally used for the management of pain, sprain, and bone fracture. In this study we have tried to incorporate bioactive components of P. bicalyculata in transdermal patches which were developed by solvent casting method. Formulated patches were further evaluated for thickness, folding endurance, moisture content and moisture reuptake. Formulations showing good folding endurance were selected for estimation of the drug content and in-vitro drug release. The patches showing drug content more than 90% and drug release 85% were selected and fitted for Zero-order kinetics. This study will help in the development of transdermal patch for the treatment of bone fracture.