ABSTRACT

Nose to brain delivery is an alternative and efficient way of delivery of drugs, protein, peptides, DNA, RNA, and plasmids for improved therapeutics in the treatment of neurological disorders. Nanotechnology enables the use of nanocarriers, such as polymer, lipid, and metal-based for delivery of an active agent to targeted site selectively and minimise other systemic side effects. Viral vectors like herpes simplex, adenovirus, and lentivirus are also used for the delivery of genes to the brain with improved transfection efficiency and transduction process. Metal-based nanomaterials such as gold and super magnetic iron oxide nanoparticles, used for theranostic application for brain-related nose to brain delivery, has proven several advantages and are discussed together with their limitations, in this review in detail.