Article Details

A COMPARATIVE STUDY OF SOLUBILITY ENHANCEMENT OF BICALUTAMIDE BY SOLID LIPID NANOPARTICLES AND SOLID DISPERSION TECHNIQUE

Rohan R. Vakhariyaa *, Indrayani D. Rauta , Dipak S. Gumateb, Jamir A. Tambolia and Shrinivas K. Mohitec

a Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Sangli – 415 404, Maharashtra, India

b Department of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Sangli – 415 404 , Maharashtra, India

c Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Sangli – 415 404 , Maharashtra, India

*For Correspondence: E-mail: rohanwakhariya@gmail.com

 

https://doi.org/10.53879/id.59.11.13175


ABSTRACT

A comparative evaluation of solid lipid nanoparticles and solid dispersion of bicalutamide using PVP K30 and stearic acid was performed. Bicalutamide solid dispersions (BL- SD) were prepared with conventional solvent evaporation method and bicalutamide solid lipid nanoparticles (BL-SLN) were prepared by precipitation method. The formulations were assessed on the standard evaluation parameters. The study demonstrated that BL-SLN was performed better as compared to (BL- SD).

Year 2022 | Volume No. 59 | Issue No.11 | Page No. 91-93
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