ABSTRACT

A precise, simple, economical and accurate UV spectroscopy-assisted method has been developed to estimate piroxicam (PRXM) in pure API and tablet dosage form. The absorbance maxima of PRXM were found at 357nm λmax using water (H₂O) and methanol (MeOH) in a ratio of 40:60 V/V as a solvent. For concentrations between 2 μg mL^-1 - 12 μg mL^-1, the procedure adheres to Beer's law with an R² value of 0.9992, the linearity was found in the calibration curve between absorbance and concentration in accordance with the line equation y=0.0508x+0.0085. The LOD and LOQ were found to be 0.90 µg mL^-1 and 2.74 µg mL^-1, respectively. The proposed method was effectively used to calculate PRXM in bulk drug and pharmaceutical formulations without common excipient influence and the % RSD was found 0.79, with an average % recovery of 99.57 %. The developed method was validated in accordance with ICH Q2 (R1) guidelines.