Article Details

Extraction, Isolation and Synthesis of Derivatives of Ursolic Acid

Babar S. B.* and Laddha K. S.

Medicinal Natural Product Research Laboratory Department of Pharmaceutical Sciences and Technology Institute of Chemical Technology Matunga, Mumbai - 400019. *E-mail:


Study was undertaken with an objective to develop a simple method for isolation of ursolic acid from Nerium indicum Mill leaves and to prepare synthetic derivatives of ursolic acid. The leaves were defatted with petroleum ether and then extracted with methanol. Methanol extract was basified and subsequently acidified, followed by charcoal treatment to isolate ursolic acid. Synthetic derivatives were prepared from isolated ursolic acid by substitution at C-3 position. The structure of ursolic acid and its derivatives were confirmed by IR, MS, 1H NMR, 13C NMR studies.
Year 2012 | Volume No. 49 | Issue No.1 | Page No. 33-37
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