Articles Accepted

by Dr. Abimbola. E Bankole, 13 Jun 2019

Objective: To examine the acute and sub-acute toxicity of the ethanolic extract of the stem and root of Aristolochia ringens and Securidaca longepedunculata respectively in wistar rats. Methods: The animals were divided into 5 per group and oral administration of extract at doses of 100, 250, 500 mg/kg were given daily for 28 days. Control group were given distilled water and animals were weighed at 7 days interval. Animals were kept under close observation for 24 hr and 28 days for acute and sub acute toxicity study respectively. Body and relative organ weight, Biochemical and Haemotological analysis, Phytochemical screening were carried out. Results: The extract did not exhibit significant change in the percentage body weight when compared to the control group. The stem extract of A. rigens did not show any significant difference in the organs weight while the root extract of S. longepedunculata exhibited a significant dose-dependent decrease in the weight of the liver and heart at all the treated groups (p

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October 2019
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