Current Issue

March  2019

  • Volume 56
  • Issue 03
  • Page Nos. 86

Guest Editorial

Opportunities in Doing the Greater Good: a Bigger Role for Pharma

PAGE 5-6

Dr. Jay Lakshman is Director/Global Technical Project Management Leader guiding the development of portfolio projects at Novartis Pharmaceuticals Corporation in US. He has been responsible for numerous INDs and three successfully launched commercial products. He has over 10 patents and 40 present...

Dr. Jay Lakshman
Director/Global Technical Project Management

Review Article

Fungal endophytes as repository of xanthine oxidase inhibitor

PAGE 7-11

Xanthine oxidase, a key enzyme of purine metabolism, is considered to be a prime target for the treatment of hyperuricemia and oxidative stress related disorders. Allopurinol and febuxostat are two FDA approved xanthine oxidase inhibitors currently being used for management of chronic hyperuricem...

Kapoor N.a, Saxena S.b and Gambhir L.c*

Original Research Articles

SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF SOME SCHIFF BASES OF 1, 3, 4-OXADIAZOLE

PAGE 12-17

A new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives has been synthesized with the help of different aromatic benzaldehydes and final compounds were characterized by FTIR and 1H NMR. 2,5- disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff ba...

Kaur Manpreeta* and Singh S.b

Synthesis and evaluation of some newer quinazolinonyl substituted benzoxazepinyl / benzothiazepinyl indoles as potent anticonvulsant agents

PAGE 18-24

new series of 3-[3-amino-2-methyl-6-substituted quinazolin-4(3H)-onyl chalconyl)-2-substituted indoles (3-8), 3-[3-Amino-2-methyl-6- substituted quinazolin-4(3H) -onyl-benzoxazepin/benzo -thiazepin- 2-yl] -2-substituted indoles (9-20) and 3-[3-amino-2-methyl-6-substituted quinazolin-4(3H) -onyl-3...

Archana*

GASTRO-PROTECTIVE POTENTIAL OF FLOWERS OF HIBISCUS ROSA-SINENSIS (L.) IN MUCOSAL LESION ON RATS

PAGE 25-31

study was conducted to evaluate the gastro-protective activity of aqueous (HAE) and ethanolic (HEE) extracts of Hibiscus rosa-sinensis Linn. (Malvaceae) flowers in experimental animals. Aqueous and ethanolic extracts were investigated for pylorus ligation and indomethacin induced ulcer models in ...

Agrawal K. K.a*, Verma A.a and Singh K.a

SIMULTANEOUS ESTIMATION OF DAPAGLIFOZIN AND SAXAGLIPTIN IN TABLETS USING two CHEMOMETRIC-ASSISTED UV-SPECTROPHOTOMETRIC METHODS

PAGE 32-38

Two simple, accurate, precise and economical UV spectrophotometric methods, Multiple Linear Regression (MLR) and Principal Component Regression (PCR), were developed for the simultaneous estimation of dapaglifozin (DAPA) and saxagliptin (SAXA) in tablets. Beer’s law was obeyed in the concentrat...

Sonawane S. S.a*, More S. S.a, Chhajed S. S.a and Kshirsagar S. J.a

Forced Degradation Studies of Olmesartan medoxomil and Chlorthalidone: Development and Validation of Stability-Indicating RP‑HPLC method

PAGE 39-45

A reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of olmesartan medoxomil (OLME) and chlorthalidone (CHLOR) in tablet dosage form. The analysis was performed on Inertsil ODS C18 (250 x 4.6 mm, 5 μ) using KH2PO4 ...

Sherje A.a* and Sonalkar A.a

CHEMOMETRICS ASSISTED STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ACETYL CYSTEINE AND AMBROXOL HYDROCHLORIDE IN BULK AND DOSAGE FORM

PAGE 46-53

A simple and precise stability indicating RP-HPLC method was developed for the simultaneous estimation of acetyl cysteine and ambroxol hydrochloride in bulk and dosage form. Experimental design based evaluation using a 23 full factorial design was applied to evaluate coefficient, ANOVA for the es...

Potluri H.a*

BINARY COMPLEXES OF GLIMEPIRIDE WITH β-CYCLODEXTRIN FOR IMPROVED SOLUBILITY AND DRUG DELIVERY

PAGE 54-60

Cyclodextrin complexation is a one of the most investigated techniques of solubility and dissolution enhancement of drugs. In the present study, a poorly water soluble drug glimepiride, was complexed with β-cyclodextrin (βCD) with the aim of improving water solubility and drug dissolution. The ...

Adhikari L.a, Semalty M.a, Naruka P. S.b, Aswal V. K.c and Semalty A.a*

DESIGN DEVELOPMENT AND OPTIMIZATION OF A SUSTAINED RELEASE TABLET OF BOSENTAN MONOHYDRATE FOR PULMONARY ARTERIAL HYPERTENSION

PAGE 61-67

Pulmonary arterial hypertension (PAH) means high blood pressure in the lungs caused by obstruction in the small arteries of the lungs.The current study involves the fabrication of oral matrix sustained release tablet of bosentan monohydrate, a dual endothelin receptor antagonist, the optimisation...

Dighe P. P.a,b* and Tank H. M.c

GASTROPROTECTIVE AND ULCER HEALING ACTIVITY OF ETHANOLIC EXTRACT OF ADIANTUM LUNULATUM

PAGE 68-73

Adiantum lunulatum is a fern found in monsoon season in Western Ghats, which is being used traditionally for many ailments such as bronchitis, cough, erysipelas and bleeding disorders. Aim of the present study was to investigate traditional claim of treating bleeding disorder and ulcer healing pr...

Deshpande M. N.a,b* and Balekar N.c

Short Notes

HYDROTROPIC SOLUBILISATION OF IRBESARTAN: MECHANISTIC STUDY AND DISSOLUTION PROFILING

PAGE 74-76

Irbesartan (IB) is a water insoluble drug belonging to BCS II that exerts its anti-hypertensive effect through the blockage of angiotensin II receptors. The aqueous insolubility of IB limits its bioavailability and overall efficacy. Hydrotrophy, a solubilization technique to achieve an augmentati...

Jose C.a, Amra K.b and Momin M.c*

ETHANOLIC EXTRACT OF ARISTOLOCHIA BRACTEOLATA FLOWER AS A NATURAL INDICATOR FOR ACID-BASE TITRATION

PAGE 77-79

In acid-base titration or acid-base neutralization reaction the change in color due to change pH of the solution is caused due to a third substance which is termed as acid-base indicator or pH indicator. Every indicator shows different range of colors at different pH ranges. Synthetic indicators ...

Vambhurkar G.a*, Jagtap A. a, Gavade A. a, Kengar M. a,
Bhutkar M. a, Randive D. a and Bhinge S.

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