Articles Accepted

Novel Periodontal Pocket Drug Delivery Systems for the Treatment of Periodontitis
by Mr. Himansu Bhusan Samal, 24 Jun 2019

Periodontitis describes a group of related inflammatory disease resulting in destruction of the tissues that support the tooth. This disease results from the growth of a diverse microflora (especially anaerobes) in the periodontal pockets and releases various bacterial enzymes, toxins and stimulation of body’s immune response. Scaling and Root planning is the basic treatment modality for periodontitis. Mechanical treatment is limited by physical impediments and biochemical considerations. Antimicrobial agents may be used as an adjunct to overcome limitations of mechanical therapy. Nonsurgical controlled intrapocket delivery of antimicrobials in the treatment of periodontitis has been investigated for the possibility of overcoming the limitations of conventional therapy. Nonsurgical controlled release formulations to deliver antibacterial to the site of periodontal pocket are designed to be of low cost, non-toxic, biocompatible, biodegradable, greater stability, non-immunogenicity and effective long-term treatment at the site of infection with reduced systemic dosing. Periodontal pockets as a drug delivery platform for designing a suitable dental localized dosage form along with its potential advantage and limitations.

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November 2020
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