Articles Accepted

Evaluation of Drug-Drug Interactions In Hospitalised Geriatric Patients At Tertiary Care Hospital
by Dr. JALPA SUTHAR, 17 Jul 2019

Background : The study planned to evaluate the prevalence, nature and severity of drug-drug interactions (DDI) in the geriatric age group. Materials and Methods: A prospective observational study was carried out in medicine and cardiac department in hospitalized patients. Study began after obtaining approval of Institutional Ethics Committee. All data were evaluated for potential drug-drug interactions (pDDIs) using medscape drug interaction checker. Result: Data of 300 patients were collected who were followed up for 3 days and analyzed over a period of 7 months. The prevalence rate of drug – drug interactions was 90.3%, as 271 out of 300 prescriptions showed drug-drug interaction. Out of 300 patients, 4797 Possible drug – drug interactions (DDIs) were identified of which 39 (0.81%) were contraindicated, 290 (6.04%) serious drug interactions, 3312 (68.85%) significant interactions and 1156 (24.09%) minor interactions. Out of 4797 Possible drug – drug interactions, 2962 (62.91%) were pharmacodynamic interactions, 1835 (37.08%) were pharmacokinetic interactions. The most common comorbid condition was hypertension which was found in 197 patients out of 300 patients.Antihypertensive class of drug showed potential for drug – drug interactions. Out of 300 cases, 244 (81.33 %) cases contained 19 potentially inappropriate medicines(PIM) prescribed to geriatric patients. Conclusion: The prevalence of drug-drug interactions (DDIs) in a geriatric patient was 90.3%. Poly pharmacy and multiple associated conditions in elderly were the major contributing factors for DDI.

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