Articles Accepted

“EVALUATION OF HYPOGLYCEMIC ACTIVITY OF Prosopis juliflora ON ALLOXAN INDUCED DIABETIC RAT MODEL”
by Ms. Manisha Dnyandeo Ukande, 01 Aug 2019

Aim of the present study was to evaluate the hypoglycemic activity of Prosopis juliflora leaf extract on Alloxan induced diabetic rats. Preliminary phytochemical investigation of Prosopis juliflora leaf extract was done according to standard tests. Standardization of PJLE was done by HPTLC analysis. PJLE (100,200,400 mg/kg) was administered to all animals group wise with standard Glibenclamide, Normal saline solution for normal control group for 21 days orally. After 21 days one animal from each group was sacrificed. Blood samples were collected for biochemical analysis and pancreas tissue was subjected to histopathological examination. Rats treated with PJLE showed significant changes in blood glucose level, body weight, organ weight, biochemical parameters there was also significant improvement in the histopathological scores in PJLE treated groups when compared with diabetic control group. This study evaluates effectiveness of PJLE as therapeutic agent in hypoglycemic activity by Alloxan induced diabetic rat model in dose dependant manner.

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October 2019
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